Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.C620W
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EGFR

NM_005228.5:p.C620W

Associated Papers

Integrating evidence from protein domains to identify cancer driver mutations.

Ostroverkhova D et al.

Protein Science : a Publication of the Protein Society, 2026

41556616 (PubMed )
Supplement: PRO-35-e70422-s002.xlsx › Table_S1

Resistance Mutation Profiles Associated with Current Treatments for Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer in the United States: A Systematic Literature Review.

Vadagam P et al.

Current Oncology (toronto, Ont.), 2025

40277748 (PubMed )
Supplement: curroncol-32-00191-s001.zip › curroncol-3409061-supplementary.pdf

Comparison between next-generation sequencing and multiplex polymerase chain reaction assays for nonsmall-cell lung cancer molecular diagnosis.

Murakami S et al.

Cancer Medicine, 2024

38572952 (PubMed )
Supplement: CAM4-13-e7162-s003.xlsx › DNA_mutations

Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants.

Hayes TK et al.

Nature Communications, 2024

38548752 (PubMed )
Supplement: 41467_2024_45594_MOESM4_ESM.xlsx › All

ERBB family fusions are recurrent and actionable oncogenic targets across cancer types.

Schubert L et al.

Frontiers in Oncology, 2023

37168365 (PubMed )
Supplement: Table_4.xlsx › EGFR_mutations

Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Liu H et al.

Cancer Communications (london, England), 2020

32067422 (PubMed )
Supplement: CAC2-40-43-s001.xlsx › Table_S1

Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches.

Ellis HP et al.

Journal of Oncology, 2019

32082376 (PubMed )
Supplement: 4878547.f1.zip › 4878547.f1 › Ellis_et_al_SNVs_041018_Supplementary_Tables.xlsx › TableS7_TCGA_mutatons

Integrative omics analyses broaden treatment targets in human cancer.

Sengupta S et al.

Genome Medicine, 2018

30053901 (PubMed )
Supplement: 13073_2018_564_MOESM2_ESM.xlsx › 13

Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The "Rotation Model".

Purba ER et al.

Cells, 2017

Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Kis O et al.

Nature Communications, 2017

28492226 (PubMed )
Supplement: ncomms15086-s1.pdf

Epidermal growth factor receptor targeting and challenges in glioblastoma.

Thorne AH et al.

Neuro-oncology, 2016

Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo.

Greenall SA et al.

Oncogene, 2015

Epidermal growth factor receptor extracellular domain mutations in primary glioblastoma.

Idbaih A et al.

Neuropathology and Applied Neurobiology, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."