Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.C624F
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EGFR

NM_005228.5:p.C624F

Associated Papers

Integrating evidence from protein domains to identify cancer driver mutations.

Ostroverkhova D et al.

Protein Science : a Publication of the Protein Society, 2026

41556616 (PubMed )
Supplement: PRO-35-e70422-s002.xlsx › Table_S1

Analysis of 1386 epileptogenic brain lesions reveals association with DYRK1A and EGFR.

Boßelmann CM et al.

Nature Communications, 2024

39616148 (PubMed )
Supplement: 41467_2024_54911_MOESM10_ESM.xlsx › Supplementary_Data_8

Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants.

Hayes TK et al.

Nature Communications, 2024

38548752 (PubMed )
Supplement: 41467_2024_45594_MOESM4_ESM.xlsx › All

ERBB family fusions are recurrent and actionable oncogenic targets across cancer types.

Schubert L et al.

Frontiers in Oncology, 2023

37168365 (PubMed )
Supplement: Table_4.xlsx › EGFR_mutations

A Genome-Wide Profiling of Glioma Patients with an IDH1 Mutation Using the Catalogue of Somatic Mutations in Cancer Database.

Pappula AL et al.

Cancers, 2021

34503108 (PubMed )
Supplement: cancers-13-04299-s001.zip › Supplemental_Tables_final.xlsx › Table_S11

Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Brown AL et al.

Plos Computational Biology, 2019

31034466 (PubMed )
Supplement: pcbi.1006981.s010.xlsx › final_benchmark

Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The "Rotation Model".

Purba ER et al.

Cells, 2017

Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo.

Greenall SA et al.

Oncogene, 2015

ErbB polymorphisms: insights and implications for response to targeted cancer therapeutics.

Alaoui-Jamali MA et al.

Frontiers in Genetics, 2015

25699077 (PubMed )
Supplement: Table1.PDF

Impact of EGFR gene polymorphisms on anticancer drug cytotoxicity in vitro.

Puyo S et al.

Molecular Diagnosis & Therapy, 2008

Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study.

Choi JE et al.

Bmc Cancer, 2007

Epidermal growth factor receptor domain II, IV, and kinase domain mutations in human solid tumors.

Sihto H et al.

Journal of Molecular Medicine (berlin, Germany), 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."