Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.L703F
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EGFR

NM_005228.5:p.L703F

Associated Papers

Osimertinib with or without savolitinib as first-line treatment for MET-aberrant, EGFR-mutant NSCLC: randomized phase 2 trial (FLOWERS).

Li A et al.

Nature Communications, 2026

41530133 (PubMed )
Supplement: 41467_2025_67950_MOESM1_ESM.pdf

Structure-Guided Strategies of Targeted Therapies for Patients with EGFR-Mutant Non-Small Cell Lung Cancer.

Du Z et al.

Biomolecules, 2023

36830579 (PubMed )
Supplement: biomolecules-13-00210-s001.zip › biomolecules-2098784-supplementary.xlsx › Table_S1

A Nationwide Study on the Impact of Routine Testing for EGFR Mutations in Advanced NSCLC Reveals Distinct Survival Patterns Based on EGFR Mutation Subclasses.

Koopman B et al.

Cancers, 2021

Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The "Rotation Model".

Purba ER et al.

Cells, 2017

DNA-Mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): a catalog of clinically relevant cancer mutations to enable genome-directed anticancer therapy.

Yeh P et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2013

Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer.

Wu JY et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

21531810 (PubMed )
Supplement: 10780432ccr103408-sup-ccr_10-3408_wu_t4.pdf

EGFR-mutated lung cancer: a paradigm of molecular oncology.

Zhang Z et al.

Oncotarget, 2010

'Classical' but not 'other' mutations of EGFR kinase domain are associated with clinical outcome in gefitinib-treated patients with non-small cell lung cancer.

Pallis AG et al.

British Journal of Cancer, 2007

Tumor Mutation Signature Reveals the Risk Factors of Lung Adenocarcinoma with EGFR or KRAS Mutation.

Wang J et al.

Cancer Control : Journal of the Moffitt Cancer Center, 0

39760242 (PubMed )
Supplement: sj-xlsx-2-ccx-10.1177_10732748241307363.xlsx › MSK
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."