Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.E709Q
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EGFR

NM_005228.5:p.E709Q

Associated Papers

Challenges associated with the treatment of E709K and L858R double mutation in lung adenocarcinoma: A case report and literature review.

Song J et al.

Oncology Letters, 2025

Detection of Overlooked Rare EGFR Mutations in Non-small Cell Lung Cancer Using Multigene Testing.

Shiraishi N et al.

Thoracic Cancer, 2025

Oncogenic composite mutations can be predicted by co-mutations and their chromosomal location.

Küçükosmanoglu A et al.

Molecular Oncology, 2024

38757376 (PubMed )
Supplement: MOL2-18-2407-s001.xlsx › 1E_Excluded_datasets

Efficacy of targeted therapy in patients with non-small cell lung cancer harboring very rare mutations in EGFR exon 18.

Zhang Y et al.

Translational Lung Cancer Research, 2024

Early-Stage Non-Small Cell Lung Cancer: Prevalence of Actionable Alterations in a Monocentric Consecutive Cohort.

Bruno R et al.

Cancers, 2024

Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.

Sakthikumar S et al.

Veterinary and Comparative Oncology, 2023

37248814 (PubMed )
Supplement: supplement_1.xlsx › Supp._Table_5

Efficacy of EGFR-Tyrosine Kinase Inhibitors for advanced non-small cell lung cancer patients harboring rare EGFR mutations of exon 18 E709X.

Hao Y et al.

Medical Oncology (northwood, London, England), 2022

Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Sobahy TM et al.

Bmc Medical Genomics, 2022

35468810 (PubMed )
Supplement: 12920_2022_1235_MOESM2_ESM.xlsx › Sheet1

Durable response to afatinib in an advanced lung adenocarcinoma patient with an EGFR L858R/G729A compound mutation: a case report.

Wu L et al.

Annals of Translational Medicine, 2022

Long term follow-up of EGFR mutated NSCLC cases.

Rennert G et al.

Translational Oncology, 2021

Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Liu H et al.

Cancer Communications (london, England), 2020

32067422 (PubMed )
Supplement: CAC2-40-43-s001.xlsx › Table_S1

Impact of Somatic Mutations in Non-Small-Cell Lung Cancer: A Retrospective Study of a Chinese Cohort.

Shen HB et al.

Cancer Management and Research, 2020

Discrepancies between ALK protein disruption and occurrence of ALK gene rearrangement in Polish NSCLC patients.

Grenda A et al.

Journal of Thoracic Disease, 2018

A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer.

Kohsaka S et al.

Science Translational Medicine, 2017

29141884 (PubMed )
Supplement: aan6566_supplementary_tables.zip › aan6566_Table_S6.xlsx › Table_S6

Clinical features and treatment outcome of non-small cell lung cancer (NSCLC) patients with uncommon or complex epidermal growth factor receptor (EGFR) mutations.

Frega S et al.

Oncotarget, 2017

Assessment of the clinical application of detecting EGFR, KRAS, PIK3CA and BRAF mutations in patients with non-small cell lung cancer using next-generation sequencing.

Xu X et al.

Scandinavian Journal of Clinical and Laboratory Investigation, 2016

Effectiveness of tyrosine kinase inhibitors on uncommon E709X epidermal growth factor receptor mutations in non-small-cell lung cancer.

Wu JY et al.

Oncotargets and Therapy, 2016

The impact of rare EGFR mutations on the treatment response of patients with non-small cell lung cancer.

Karachaliou N et al.

Expert Review of Respiratory Medicine, 2015

A systematic profile of clinical inhibitors responsive to EGFR somatic amino acid mutations in lung cancer: implication for the molecular mechanism of drug resistance and sensitivity.

Ai X et al.

Amino Acids, 2014

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology.

Lindeman NI et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2013

Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology.

Lindeman NI et al.

Archives of Pathology & Laboratory Medicine, 2013

Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer.

Wu JY et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

21531810 (PubMed )
Supplement: 10780432ccr103408-sup-ccr_10-3408_wu_t4.pdf

Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events.

Chen Z et al.

Plos One, 2008

19005564 (PubMed )
Supplement: pone.0003714.s003.xls › Table_S-1

Epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer: impact of primary or secondary mutations.

Sakurada A et al.

Clinical Lung Cancer, 2006

Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer.

Chou TY et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2005

[Molecular profiling of non-small cell lung cancer].

Gibault L et al.

Revue De Pneumologie Clinique, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."