Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.E709A
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EGFR

NM_005228.5:p.E709A

Associated Papers

Mutational landscape of lung adenocarcinoma in Czechia.

Ambrozkiewicz F et al.

Cancer Treatment and Research Communications, 2026

Amivantamab Plus Lazertinib in Atypical EGFR-Mutated Advanced Non-Small Cell Lung Cancer: Results From CHRYSALIS-2.

Tomasini P et al.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 2026

Prevalence of Genomic Alterations in EGFR, KRAS, NRAS, and BRAF Among Early-Stage Nonsquamous Non-Small Cell Lung Cancer in Brazil.

Marques FK et al.

Jco Global Oncology, 2026

A prospective, multicenter, comprehensive genomic profile signature study in patients with EGFR-mutant advanced non-small cell lung cancer at the first-line treatment failure of osimertinib.

Shi Y et al.

Signal Transduction and Targeted Therapy, 2025

41326340 (PubMed )
Supplement: 41392_2025_2481_MOESM1_ESM.docx

Clinical outcomes of EGFR-TKI in advanced lung squamous cell carcinoma and EGFR-TKI remodel tumor immune microenvironment.

Chen Z et al.

Annals of Medicine, 2025

Flat Cell Variant of Lung Adenocarcinoma In Situ.

Oka N et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2025

Challenges associated with the treatment of E709K and L858R double mutation in lung adenocarcinoma: A case report and literature review.

Song J et al.

Oncology Letters, 2025

Liquid biopsy in BALF is now suitable for clinical practice in patients with suspected NSCLC.

Borm FJ et al.

Lung Cancer (amsterdam, Netherlands), 2025

Single-cell RNA profiling reveals an immunosuppressive microenvironment in EGFR double-mutant non-small cell lung cancer.

Yang J et al.

Translational Lung Cancer Research, 2025

41234595 (PubMed )
Supplement: tlcr-14-10-4235-supplementary.pdf

Discriminating activating, deactivating and resistance variants in protein kinases.

Singh G et al.

Genome Medicine, 2025

41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S6

Discovery of Novel RASGRF2 Fusions as a Therapeutic Target in Lung Adenocarcinoma of Never or Light Smokers.

Terashima Y et al.

Cancer Science, 2025

40734624 (PubMed )
Supplement: CAS-116-2868-s002.xlsx › Table_S5

Clinical factors and molecular co-alterations impact outcomes in patients receiving first-line osimertinib for EGFR-mutated non-small cell lung cancer.

Sun F et al.

Lung Cancer (amsterdam, Netherlands), 2025

Lazertinib for Patients with NSCLC Harboring Uncommon EGFR Mutations: A Phase II Multicenter Trial.

Park S et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2025

Clinical utility of liquid biopsy next-generation sequencing for advanced non-small cell lung cancer in the Netherlands.

de Bitter TJJ et al.

Scientific Reports, 2025

40830613 (PubMed )
Supplement: 41598_2025_13667_MOESM2_ESM.xlsx › Supplementary_Table_3

An in-depth exploration of four heterogeneity structure-based EGFR mutation subgroups in Chinese non-small cell lung cancer.

Yu Y et al.

Bmc Pulmonary Medicine, 2025

40611150 (PubMed )
Supplement: 12890_2025_3774_MOESM1_ESM.xlsx › Sheet1

Assessing mutation-clinical correlations and treatment outcomes in Vietnamese non-small cell lung cancer patients.

Nguyen HB et al.

Practical Laboratory Medicine, 2025

Circulating tumor DNA profiling for non-invasive genomic analysis in Indian lung cancer patients: A real-world experience.

Jha P et al.

The Journal of Liquid Biopsy, 2025

40503459 (PubMed )
Supplement: mmc1.xlsx › Supplementary_Table_S2

Detection of actionable mutations in circulating tumor DNA for non-small cell lung cancer patients.

van der Leest P et al.

Communications Medicine, 2025

40437208 (PubMed )
Supplement: 43856_2025_921_MOESM4_ESM.xlsx › Blad1

Neratinib Efficacy in Patients With EGFR Exon 18-Mutant Non-Small-Cell Lung Cancer: Findings From the SUMMIT Basket Trial.

Goldman JW et al.

Clinical Lung Cancer, 2025

Frequency of targetable genetic alterations in resectable lung adenocarcinoma: Results from the LORD project.

Bossé Y et al.

Lung Cancer (amsterdam, Netherlands), 2025

Decoding the Clinical and Molecular Signatures of EGFR Common, Compound, and Uncommon Mutations in NSCLC: A Brief Report.

Tavernari D et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2025

Detection of Overlooked Rare EGFR Mutations in Non-small Cell Lung Cancer Using Multigene Testing.

Shiraishi N et al.

Thoracic Cancer, 2025

Importance of driver gene mutation assessment and targeted therapy for patients with early‑stage non‑small cell lung cancer and non‑R0 resection.

Shen PY et al.

Oncology Letters, 2025

39512503 (PubMed )
Supplement: Supplementary_Data2.pdf

Intrathecal pemetrexed improves survival outcomes in previously treated EGFR-mutant advanced non-small-cell lung cancer with leptomeningeal metastases.

Li L et al.

Heliyon, 2024

39759323 (PubMed )
Supplement: mmc1.docx

Landscape of Clinically Relevant Genomic Alterations in the Indian Non-small Cell Lung Cancer Patients.

Jha P et al.

Clinical Lung Cancer, 2024

Deciphering resistance mechanisms in cancer: final report of MATCH-R study with a focus on molecular drivers and PDX development.

Vasseur D et al.

Molecular Cancer, 2024

Beyond tobacco: genomic disparities in lung cancer between smokers and never-smokers.

Garrido J et al.

Bmc Cancer, 2024

39097719 (PubMed )
Supplement: 12885_2024_12737_MOESM2_ESM.xlsx › Table_S1

From Rarity to Reality: Osimertinib's Promising Horizon in Treating Uncommon EGFR Mutations in Non-Small Cell Lung Cancer.

Fukuda A et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

Outcomes in non-small cell lung cancer with uncommon epidermal growth factor receptor L858 substitutions under first-line epidermal growth factor receptor tyrosine kinase inhibitors: A large real-world cohort study.

Shao Y et al.

Cancer Science, 2024

38932450 (PubMed )
Supplement: CAS-115-2751-s001.pdf

Development of a genome atlas for discriminating benign, preinvasive, and invasive lung nodules.

Liang P et al.

Medcomm, 2024

Unveiling the Landscape of Uncommon EGFR Mutations in NSCLC-A Systematic Review.

Borgeaud M et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2024

Co-occurring EGFR p.E709X Mutation Mediates Primary Resistance to the Third-Generation EGFR-TKIs in EGFR p.G719X-Mutant Patients with Advanced NSCLC.

Pang L et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

Oncogene-Driven Non-Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations.

Huang CY et al.

Cancer Research, 2024

38587551 (PubMed )
Supplement: can-23-2551_supplementary_tables_suppst.xlsx › Table.S11

Activity of osimeRTInib in non-small-cell lung Cancer with UNcommon epidermal growth factor receptor mutations: retrospective Observational multicenter study (ARTICUNO).

Pizzutilo EG et al.

Esmo Open, 2024

Comparison of diagnostic performance between Oncomine Dx target test and AmoyDx panel for detecting actionable mutations in lung cancer.

Nagakubo Y et al.

Scientific Reports, 2024

Clinical relevance of somatic mutations in Chinese lung adenocarcinoma and their prognostic implications for survival.

Li T et al.

Cancer Medicine, 2024

38770632 (PubMed )
Supplement: CAM4-13-e7227-s001.xlsx › Table_S2

Efficacy of targeted therapy in patients with non-small cell lung cancer harboring very rare mutations in EGFR exon 18.

Zhang Y et al.

Translational Lung Cancer Research, 2024

Early-Stage Non-Small Cell Lung Cancer: Prevalence of Actionable Alterations in a Monocentric Consecutive Cohort.

Bruno R et al.

Cancers, 2024

Current management of uncommon EGFR mutations in non-small cell lung cancer.

Trinh JQ et al.

Current Problems in Cancer, 2024

Comparison between next-generation sequencing and multiplex polymerase chain reaction assays for nonsmall-cell lung cancer molecular diagnosis.

Murakami S et al.

Cancer Medicine, 2024

38572952 (PubMed )
Supplement: CAM4-13-e7162-s003.xlsx › DNA_mutations

Targeted next-generation sequencing of 491 lung cancers in clinical practice: Implications for future detection strategy and targeted therapy.

Liu XD et al.

Heliyon, 2024

38496837 (PubMed )
Supplement: mmc1.xlsx › Sheet1

Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants.

Hayes TK et al.

Nature Communications, 2024

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."