Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.E746del1
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EGFR

NM_005228.5:p.E746del1

Associated Papers

Brief Report: The Effectiveness of Osimertinib in Advanced Nonsmall Cell Lung Cancer Harboring Various EGFR Exon 19 Mutation Variants.

Chang LC et al.

Clinical Lung Cancer, 2025

Detection of Overlooked Rare EGFR Mutations in Non-small Cell Lung Cancer Using Multigene Testing.

Shiraishi N et al.

Thoracic Cancer, 2025

Patients with Advanced Non-Small Cell Lung Cancer and the EGFR Exon 19 Deletion p.L747 Benefit from Chemotherapy and First-Generation Tyrosine Kinase Inhibitors Compared with Patients with p.E746.

Guan M et al.

Oncotargets and Therapy, 2025

Phase II Trial of Afatinib in Patients With EGFR-Mutated Solid Tumors Excluding Lung Cancer: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol A.

Gettinger SN et al.

Jco Precision Oncology, 2024

Unravelling the role of PLK1 in tumorigenesis by revealing the mutational landscape of colorectal and lung cancer with PLK1 mutations.

Wang S et al.

Journal of Cellular and Molecular Medicine, 2024

38887977 (PubMed )
Supplement: JCMM-28-e18497-s002.xlsx › Sheet1

RELAY, Erlotinib Plus Ramucirumab in Untreated, EGFR-Mutated, Metastatic NSCLC: Outcomes by EGFR Exon 19 Deletion Variants.

Nishino K et al.

Jto Clinical and Research Reports, 2024

Efficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19 Deletion Mutations.

Grant MJ et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2023

Impact of EGFR exon 19 deletion subtypes on clinical outcomes in EGFR-TKI-Treated advanced non-small-cell lung cancer.

Huang LT et al.

Lung Cancer (amsterdam, Netherlands), 2022

Palindromic-assisted self-annealing transcription amplification for reliable genotyping of epidermal growth factor receptor exon mutations.

Yuan R et al.

Biosensors & Bioelectronics, 2021

Presentation of EGFR mutations in 162 family probands with multiple primary lung cancer.

Li C et al.

Translational Lung Cancer Research, 2021

Significant Benefits of Osimertinib Against Adenosquamous Carcinoma Harboring Germline T790M Mutation.

Huo R et al.

The Oncologist, 2020

Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Mack PC et al.

Cancer, 2020

32365229 (PubMed )
Supplement: CNCR-126-3219-s002.docx

Differential significance of molecular subtypes which were classified into EGFR exon 19 deletion on the first line afatinib monotherapy.

Tokudome N et al.

Bmc Cancer, 2020

Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance.

Batta N et al.

World Journal of Surgical Oncology, 2019

EGFR-Mutant Non-Small Cell Lung Cancer in the Era of Precision Medicine: Importance of Germline EGFR T790M Testing.

Sukari A et al.

Journal of the National Comprehensive Cancer Network : Jnccn, 2017

The Roche Cancer Genome Database (RCGDB).

Küntzer J et al.

Human Mutation, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."