Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.I759M
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EGFR

NM_005228.5:p.I759M

Associated Papers

TP53 Functional-Domain-Specific Mutations Define Distinct Clinical Outcomes in EGFR-Mutant Non-Small Cell Lung Cancer Treated with EGFR Tyrosine Kinase Inhibitors.

Kobayashi K

Journal of Clinical Medicine, 2026

41753239 (PubMed )
Supplement: jcm-15-01552-s001.zip › jcm-4078632-supplementary.pdf

Clinical utility and predictive value of cerebrospinal fluid cell-free DNA profiling in non-small cell lung cancer patients with leptomeningeal metastasis.

Liang SK et al.

Neoplasia (new York, N.y.), 2025

Oncogene-Driven Non-Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations.

Huang CY et al.

Cancer Research, 2024

38587551 (PubMed )
Supplement: can-23-2551_supplementary_tables_suppst.xlsx › Table.S11

Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants.

Hayes TK et al.

Nature Communications, 2024

38548752 (PubMed )
Supplement: 41467_2024_45594_MOESM4_ESM.xlsx › All

Structure-Guided Strategies of Targeted Therapies for Patients with EGFR-Mutant Non-Small Cell Lung Cancer.

Du Z et al.

Biomolecules, 2023

36830579 (PubMed )
Supplement: biomolecules-13-00210-s001.zip › biomolecules-2098784-supplementary.xlsx › Table_S1

Relationship between driver gene mutations and clinical pathological characteristics in older lung adenocarcinoma.

Liu X et al.

Frontiers in Oncology, 2023

38023198 (PubMed )
Supplement: Table_1.xlsx › Table_S2

Inter- and Intratumor Heterogeneity of EGFR Compound Mutations in Non-Small Cell Lung Cancers: Analysis of Five Cases.

Suda K et al.

Clinical Lung Cancer, 2021

Oncogenic mutations within the β3-αC loop of EGFR/ERBB2/BRAF/MAP2K1 predict response to therapies.

Zhang B et al.

Molecular Genetics & Genomic Medicine, 2020

The effectiveness of afatinib in patients with lung adenocarcinoma harboring complex epidermal growth factor receptor mutation.

Wu SG et al.

Therapeutic Advances in Medical Oncology, 2020

Barcode sequencing identifies resistant mechanisms to epidermal growth factor receptor inhibitors in circulating tumor DNA of lung cancer patients.

Kitazono S et al.

Cancer Science, 2019

A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer.

Kohsaka S et al.

Science Translational Medicine, 2017

Identical epidermal growth factor receptor mutations in adenocarcinomatous and squamous cell carcinomatous components of adenosquamous carcinoma of the lung.

Kang SM et al.

Cancer, 2007

Tumor Mutation Signature Reveals the Risk Factors of Lung Adenocarcinoma with EGFR or KRAS Mutation.

Wang J et al.

Cancer Control : Journal of the Moffitt Cancer Center, 0

39760242 (PubMed )
Supplement: sj-xlsx-2-ccx-10.1177_10732748241307363.xlsx › Asian
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."