Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.H773_V774ins3
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EGFR

NM_005228.5:p.H773_V774ins3

Associated Papers

Mutational landscape of lung adenocarcinoma in Czechia.

Ambrozkiewicz F et al.

Cancer Treatment and Research Communications, 2026

Discovery of Novel RASGRF2 Fusions as a Therapeutic Target in Lung Adenocarcinoma of Never or Light Smokers.

Terashima Y et al.

Cancer Science, 2025

40734624 (PubMed )
Supplement: CAS-116-2868-s002.xlsx › Table_S1

Circulating Tumor DNA in Advanced EGFRex20+ NSCLC: Concordance with Tissue Biopsy, Monitoring of Response, and Resistance to High-Dose Osimertinib.

Zwierenga F et al.

Targeted Oncology, 2025

Detection of actionable mutations in circulating tumor DNA for non-small cell lung cancer patients.

van der Leest P et al.

Communications Medicine, 2025

40437208 (PubMed )
Supplement: 43856_2025_921_MOESM4_ESM.xlsx › Blad1

Genetic alterations affect immune contexture of non-small cell lung cancer: Ukrainian study.

Kozakov D et al.

Frontiers in Medicine, 2025

The relevance of the reference range for EGFR testing in non-small cell lung cancer patients.

Pisapia P et al.

Lung Cancer (amsterdam, Netherlands), 2024

Spindle Cell Lesions with Oncogenic EGFR Kinase Domain Aberrations: Expanding the Spectrum of Protein Kinase-Related Mesenchymal Tumors.

Vallese S et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2024

Multinational proficiency tests for EGFR exon 20 insertions reveal that the assay design matters.

Ihle MA et al.

Scientific Reports, 2024

Novel EGFR mutations in diffuse midline gliomas using cost-effective strategies: A report of 2 cases.

Dandapath I et al.

Neuro-oncology Practice, 2024

Comprehensive analysis of next generation sequencing and ARMS-PCR for detecting EGFR exon 20 insertion (ex20ins) mutations in Chinese non-small cell lung cancer patients.

Xu Y et al.

Translational Lung Cancer Research, 2024

External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium.

van der Leest P et al.

Clinical Chemistry, 2024

Simulation analysis of EGFR mutation detection: Oncomine Dx target test and AmoyDx panel impact on lung cancer treatment decisions.

Hirotsu Y et al.

Scientific Reports, 2024

38238401 (PubMed )
Supplement: 41598_2024_52006_MOESM1_ESM.xlsx › Supplementary_Table_all_list

Association of mutation profiles with metastasis in patients with non-small cell lung cancer.

Li Y et al.

Frontiers in Oncology, 2024

39464712 (PubMed )
Supplement: Table3.xlsx › LMG____

Detection and Monitoring of Tumor-Derived Mutations in Circulating Tumor DNA Using the UltraSEEK Lung Panel on the MassARRAY System in Metastatic Non-Small Cell Lung Cancer Patients.

Leest PV et al.

International Journal of Molecular Sciences, 2023

37686200 (PubMed )
Supplement: ijms-24-13390-s001.zip › ijms-2558089-supplementary.pdf

Frequent EGFR exon 20 insertion in the so-called peripheral-type squamous cell neoplasm of uncertain malignant potential: a variant of bronchiolar adenoma or under-recognised entity?

Zheng Q et al.

Histopathology, 2023

FACILITATE: A real-world, multicenter, prospective study investigating the utility of a rapid, fully automated real-time PCR assay versus local reference methods for detecting epidermal growth factor receptor variants in NSCLC.

Behnke A et al.

Pathology Oncology Research : Por, 2023

ERBB family fusions are recurrent and actionable oncogenic targets across cancer types.

Schubert L et al.

Frontiers in Oncology, 2023

37168365 (PubMed )
Supplement: Table_3.xlsx › EGFR_mutations

Prospective genomically guided identification of "early/evolving" and "undersampled" IDH-wildtype glioblastoma leads to improved clinical outcomes.

Zhang Y et al.

Neuro-oncology, 2022

35395677 (PubMed )
Supplement: noac089_suppl_supplementary_tables_s1-s11.xlsx › Table_S5_SNV_data

Landscape of EGFR mutations in lung adenocarcinoma: a single institute experience with comparison of PANAMutyper testing and targeted next-generation sequencing.

Lee J et al.

Journal of Pathology and Translational Medicine, 2022

A lung adenocarcinoma patient with co-mutations of MET and EGFR exon20 insertion responded to crizotinib.

Chen Y et al.

Bmc Medical Genomics, 2022

Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

Chevrier S et al.

International Journal of Molecular Medicine, 2022

35244186 (PubMed )
Supplement: Supplementary_Data2.xlsx › Feuil1

Variation in targetable genomic alterations in non-small cell lung cancer by genetic ancestry, sex, smoking history, and histology.

Adib E et al.

Genome Medicine, 2022

35428358 (PubMed )
Supplement: 13073_2022_1041_MOESM2_ESM.xlsx › S2_EGFR_Druggable

Actionable Molecular Alterations Are Revealed in Majority of Advanced Non-Small Cell Lung Cancer Patients by Genomic Tumor Profiling at Progression after First Line Treatment.

Frank MS et al.

Cancers, 2021

35008297 (PubMed )
Supplement: cancers-14-00132-s001.zip › Supplementary_Table_S1.xlsx › Overview_ver2

Mismatch Repair Deficiency and Somatic Mutations in Human Sinonasal Tumors.

Hieggelke L et al.

Cancers, 2021

34885191 (PubMed )
Supplement: cancers-13-06081-s001.zip › Table_S3_Targeted_panel_sequencing_result_of_sinonasal_tumor_cohort.pdf

Evaluation of the Mutation Profile via Next-Generation Sequencing in a Turkish Population With Non-small Cell Lung Cancer.

Kahraman Çetin N et al.

Balkan Medical Journal, 2021

EGFR analysis on scrapings from cytology smears in lung carcinoma, an effective alternative to testing on trucut biopsies.

Mohan AA et al.

Diagnostic Cytopathology, 2021

Primary lung adenocarcinoma in three adolescent patients affected by bone sarcomas.

Righi L et al.

Virchows Archiv : an International Journal of Pathology, 2021

Morphological, immunohistochemical, and genetic analyses of bronchiolar adenoma and its putative variants.

Shao J et al.

The Journal of Pathology. Clinical Research, 2021

Sputum cell-free DNA: Valued surrogate sample for the detection of EGFR exon 20 p.T790M mutation in patients with advanced lung adenocarcinoma and acquired resistance to EGFR-TKIs.

Wang Z et al.

Cancer Medicine, 2021

33932095 (PubMed )
Supplement: CAM4-10-3323-s001.docx

Integrated Analysis of Genomic and Immunological Features in Lung Adenocarcinoma With Micropapillary Component.

Zhang S et al.

Frontiers in Oncology, 2021

34221970 (PubMed )
Supplement: Table_5.xlsx › Supplementary_Table_S5

Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Li J et al.

Journal of Translational Medicine, 2020

32738923 (PubMed )
Supplement: 12967_2020_2449_MOESM1_ESM.xlsx › Supplementary_Table_S2

Technical Evaluation of Commercial Mutation Analysis Platforms and Reference Materials for Liquid Biopsy Profiling.

Weber S et al.

Cancers, 2020

32560092 (PubMed )
Supplement: cancers-12-01588-s001.zip › Table_S7.xlsx › Table_S7

Detection of rare and novel EGFR mutations in NSCLC patients: Implications for treatment-decision.

Sousa AC et al.

Lung Cancer (amsterdam, Netherlands), 2020

The Comprehensive Analyses of Genomic Variations and Assessment of TMB and PD-L1 Expression in Chinese Lung Adenosquamous Carcinoma.

Cheng Y et al.

Frontiers in Genetics, 2020

33679868 (PubMed )
Supplement: Table_3.XLSX › Sheet1

Multicenter Evaluation of the Fully Automated PCR-Based Idylla EGFR Mutation Assay on Formalin-Fixed, Paraffin-Embedded Tissue of Human Lung Cancer.

Evrard SM et al.

The Journal of Molecular Diagnostics : Jmd, 2019

Clinical Outcomes of EGFR Exon 20 Insertion Mutations in Advanced Non-small Cell Lung Cancer in Korea.

Byeon S et al.

Cancer Research and Treatment, 2019

Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling.

Plagnol V et al.

Plos One, 2018

29543828 (PubMed )
Supplement: pone.0193802.s007.xlsx › Table_S7

Clinical mutational profiling of 1006 lung cancers by next generation sequencing.

Illei PB et al.

Oncotarget, 2017

29228562 (PubMed )
Supplement: oncotarget-08-96684-s002.docx

Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications.

Li SD et al.

Genome Medicine, 2017

29082853 (PubMed )
Supplement: 13073_2017_478_MOESM1_ESM.xlsx › Table_S2

Significant Improvement in Detecting BRAF, KRAS, and EGFR Mutations Using Next-Generation Sequencing as Compared with FDA-Cleared Kits.

Ma W et al.

Molecular Diagnosis & Therapy, 2017

EGFR Exon 20 Insertion/Duplication Mutation in Fibrous Hamartoma of Infancy With Predominantly Pseudoangiomatous Pattern Mimicking Giant Cell Fibroblastoma.

Ellington N et al.

International Journal of Surgical Pathology, 2017

EGFR Mutation Subtypes Influence Survival Outcomes following First-Line Gefitinib Therapy in Advanced Asian NSCLC Patients.

Sutiman N et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2017

EGFR Exon 20 Insertion/Duplication Mutations Characterize Fibrous Hamartoma of Infancy.

Park JY et al.

The American Journal of Surgical Pathology, 2016

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."