Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.V774L
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EGFR

NM_005228.5:p.V774L

Associated Papers

Prevalence, clinical and molecular characteristics of early stage EGFR-mutated lung cancer in a real-life West-European cohort: Implications for adjuvant therapy.

Hondelink LM et al.

European Journal of Cancer (oxford, England : 1990), 2023

Structure-Guided Strategies of Targeted Therapies for Patients with EGFR-Mutant Non-Small Cell Lung Cancer.

Du Z et al.

Biomolecules, 2023

Ultrasensitive analysis of genetic instability related to chemical exposure.

Domoradzki T et al.

Journal of Applied Genetics, 2022

Targeting rare and non-canonical driver variants in NSCLC - An uncharted clinical field.

Volckmar AL et al.

Lung Cancer (amsterdam, Netherlands), 2021

Routine Molecular Screening of Patients with Advanced Non-SmallCell Lung Cancer in Circulating Cell-Free DNA at Diagnosis and During Progression Using OncoBEAMTM EGFR V2 and NGS Technologies.

Garcia J et al.

Molecular Diagnosis & Therapy, 2021

Detection of rare and novel EGFR mutations in NSCLC patients: Implications for treatment-decision.

Sousa AC et al.

Lung Cancer (amsterdam, Netherlands), 2020

Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells.

Craig DJ et al.

Bmc Cancer, 2019

Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma.

Krug AK et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2018

29216356 (PubMed )
Supplement: mdx765_suppl_data.zip › mdx765_supp_s3.pdf

Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer.

Wu JY et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

21531810 (PubMed )
Supplement: 10780432ccr103408-sup-ccr_10-3408_wu_t4.pdf

The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors.

Stehr H et al.

Molecular Cancer, 2011

21575214 (PubMed )
Supplement: 1476-4598-10-54-S3.XLS › mutations.txt

Good response to gefitinib in lung adenocarcinoma of complex epidermal growth factor receptor (EGFR) mutations with the classical mutation pattern.

Wu SG et al.

The Oncologist, 2008

Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients.

Pugh TJ et al.

Bmc Cancer, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."