Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.E804K
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EGFR

NM_005228.5:p.E804K

Associated Papers

Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1.

He X et al.

Cell Research, 2025

Structure-Guided Strategies of Targeted Therapies for Patients with EGFR-Mutant Non-Small Cell Lung Cancer.

Du Z et al.

Biomolecules, 2023

36830579 (PubMed )
Supplement: biomolecules-13-00210-s001.zip › biomolecules-2098784-supplementary.xlsx › Table_S8

Clinical Application of Comprehensive Genomic Profiling Tests for Diffuse Gliomas.

Omura T et al.

Cancers, 2022

35626060 (PubMed )
Supplement: cancers-14-02454-s001.zip › cancers-1674301-SI.xlsx › VUS

Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Ikeuchi H et al.

Oncogene, 2022

35304574 (PubMed )
Supplement: 41388_2022_2263_MOESM5_ESM.xlsx › Supplementary_Table_4

ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications.

Jin W

Journal of Clinical Medicine, 2020

Mutational Profiling of Driver Tumor Suppressor and Oncogenic Genes in Brazilian Malignant Pleural Mesotheliomas.

Campanella NC et al.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology, 2020

Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma.

Krug AK et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2018

29216356 (PubMed )
Supplement: mdx765_suppl_data.zip › mdx765_supp_s3.pdf

High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods.

Su D et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2017

28882180 (PubMed )
Supplement: 13046_2017_591_MOESM8_ESM.xls › Table_S8__The_golden_standard_s

Analysis of progression-free survival of first-line tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring leu858Arg or exon 19 deletions.

Kuan FC et al.

Oncotarget, 2017

27935868 (PubMed )
Supplement: oncotarget-08-1343-s001.pdf

Rare and novel epidermal growth factor receptor mutations in non-small-cell lung cancer and lack of clinical response to gefitinib in two cases.

Sharma A et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2012

Association between tumor epidermal growth factor receptor mutation and pulmonary tuberculosis in patients with adenocarcinoma of the lungs.

Luo YH et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2012

Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer.

Wu JY et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

Good response to gefitinib in lung adenocarcinoma of complex epidermal growth factor receptor (EGFR) mutations with the classical mutation pattern.

Wu SG et al.

The Oncologist, 2008

Novel mutations of epidermal growth factor receptor in localized prostate cancer.

Douglas DA et al.

Frontiers in Bioscience : a Journal and Virtual Library, 2006

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."