Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.P848L
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EGFR

NM_005228.5:p.P848L

Associated Papers

Mutational landscape of lung adenocarcinoma in Czechia.

Ambrozkiewicz F et al.

Cancer Treatment and Research Communications, 2026

Germline EGFR T790M in Lung Cancer: Prevalence, Clinical Impact, and Implications for Hereditary Risk.

Melikova LA et al.

Cancer Prevention Research (philadelphia, Pa.), 2025

Germline EGFR T790M in Lung Cancer: Prevalence, Clinical Impact, and Implications for Hereditary Risk.

Melikova LA et al.

Cancer Prevention Research (philadelphia, Pa.), 2025

Discriminating activating, deactivating and resistance variants in protein kinases.

Singh G et al.

Genome Medicine, 2025

41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S6

Germline mutation analysis and postoperative recurrence risk prediction in breast cancer patients from western China.

Deng Z et al.

Translational Oncology, 2025

40738016 (PubMed )
Supplement: mmc3.xlsx › Table_S2

Somatic mutations in Middle East and North Africa breast cancer patients: a systematic review.

Abujamous L et al.

The Oncologist, 2025

40665690 (PubMed )
Supplement: oyaf205_supplementary_data.zip › SupplementaryTable3.xlsx › SupplementaryTable3

Predictors of patients with advanced pancreatic cancer undergoing conversion surgery via chemoimmunotherapy with a multifunctional Wilms' tumor 1 (WT1) peptide cocktail-pulsed dendritic cell vaccine.

Koido S et al.

Journal for Immunotherapy of Cancer, 2025

An in-depth exploration of four heterogeneity structure-based EGFR mutation subgroups in Chinese non-small cell lung cancer.

Yu Y et al.

Bmc Pulmonary Medicine, 2025

40611150 (PubMed )
Supplement: 12890_2025_3774_MOESM1_ESM.xlsx › Sheet1

Genetic Ancestry and Lung Cancer in Latin American Patients: A Crucial Step for Understanding a Diverse Population.

Castañeda-González JP et al.

Clinical Lung Cancer, 2025

Comprehensive molecular profiling of advanced NSCLC using NGS: Prevalence of druggable mutations and clinical trial opportunities in the ATLAS study.

Serna-Blasco R et al.

Lung Cancer (amsterdam, Netherlands), 2025

Distribution of EGFR and KRAS Mutations in Patients with Surgically Resected Non-Small Cell Lung Cancer from Southern Italy: Real-Life Data from a Single Institution and Literature Review.

Piazzolla M et al.

Cancers, 2025

40075579 (PubMed )
Supplement: cancers-17-00730-s001.zip › cancers-3468545-supplementary.xlsx › EGFRmutated_profile_SupplTab2

Case Report: Gefitinib in EGFR 19del recurrent aggressive fibromatosis.

Guo Y et al.

Frontiers in Oncology, 2025

Beyond HRD Status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer.

Kjeldsen MK et al.

Cancer Research Communications, 2024

39591206 (PubMed )
Supplement: crc-24-0294_supplementarygenetable_s1_suppst1.xlsx › SupplementaryGeneTableS1

Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors.

Burr R et al.

Nature Cancer, 2024

Benefits of osimertinib treat a lung adenocarcinoma patient with germline EGFR T790M, somatic EGFR 19-Del, TP53 and PIK3CA mutations.

Li Y et al.

Hereditary Cancer in Clinical Practice, 2024

Germline variants in patients diagnosed with pediatric soft tissue sarcoma.

Yndestad S et al.

Acta Oncologica (stockholm, Sweden), 2024

A patient with a Germline (p.R776H) EGFR Mutation With Multiple Lung Cancers Harboring Different Somatic EGFR Mutations.

Petrini I et al.

Clinical Lung Cancer, 2024

Efficacy of immunotherapy in ARID1A-mutant solid tumors: a single-center retrospective study.

Zhou H et al.

Discover Oncology, 2024

38847966 (PubMed )
Supplement: 12672_2024_1074_MOESM2_ESM.xlsx › Sheet1

Single nucleotide variants in lung cancer.

Tian X et al.

Chinese Medical Journal Pulmonary and Critical Care Medicine, 2024

Utility of multigene panel next-generation sequencing in routine clinical practice for identifying genomic alterations in newly diagnosed metastatic nonsmall cell lung cancer.

Nindra U et al.

Internal Medicine Journal, 2024

Mutations Detected in Real World Clinical Sequencing during BTK Inhibitor Treatment in CLL.

Brown J et al.

Research Square, 2024

Molecular pathology of non-small cell carcinoma.

Yatabe Y

Histopathology, 2024

The rapidly changing field of predictive biomarkers of non-small cell lung cancer.

Tóth LJ et al.

Pathology Oncology Research : Por, 2024

Genomic profiling of NSCLC tumors with the TruSight oncology 500 assay provides broad coverage of clinically actionable genomic alterations and detection of known and novel associations between genomic alterations, TMB, and PD-L1.

Wallen ZD et al.

Frontiers in Oncology, 2024

39664186 (PubMed )
Supplement: Table2.xlsx › Supplementary_Table_2

Germline mutations and developmental mosaicism underlying EGFR-mutant lung cancer.

Burr R et al.

Medrxiv : the Preprint Server for Health Sciences, 2023

Germline EGFR mutations in lung cancer (Review).

Liu M et al.

Oncology Letters, 2023

Overview on Therapeutic Options in Uncommon EGFR Mutant Non-Small Cell Lung Cancer (NSCLC): New Lights for an Unmet Medical Need.

Pretelli G et al.

International Journal of Molecular Sciences, 2023

Optimal therapy for concomitant EGFR and TP53 mutated non-small cell lung cancer: a real-world study.

Sun H et al.

Bmc Cancer, 2023

Rare mutation-dominant compound EGFR-positive NSCLC is associated with enriched kinase domain-resided variants of uncertain significance and poor clinical outcomes.

Zhao W et al.

Bmc Medicine, 2023

36829178 (PubMed )
Supplement: 12916_2023_2768_MOESM1_ESM.docx

Case report: identification of EGFR R776H and FANCE R381H germline mutations in a patient with multiple pulmonary nodules.

Wu Z et al.

Journal of Cancer Research and Clinical Oncology, 2023

Clinically relevant germline variants in allogeneic hematopoietic stem cell transplant recipients.

Lahtinen AK et al.

Bone Marrow Transplantation, 2023

36195768 (PubMed )
Supplement: 41409_2022_1828_MOESM1_ESM.docx

Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor.

Machado-Rugolo J et al.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologica, 2023

ERBB family fusions are recurrent and actionable oncogenic targets across cancer types.

Schubert L et al.

Frontiers in Oncology, 2023

37168365 (PubMed )
Supplement: Table_4.xlsx › EGFR_mutations

Relationship between driver gene mutations and clinical pathological characteristics in older lung adenocarcinoma.

Liu X et al.

Frontiers in Oncology, 2023

38023198 (PubMed )
Supplement: Table_1.xlsx › Table_S2

Molecular Divergence upon EGFR-TKI Resistance Could Be Dependent on the Exon Location of the Original EGFR-Sensitizing Mutation.

Serna-Blasco R et al.

Cancers, 2022

36139605 (PubMed )
Supplement: cancers-14-04446-s001.zip › Supplemental_data_S2.xlsx › dPCR_assays

Clinical value of next-generation sequencing in guiding decisions regarding endocrine therapy for advanced HR-positive/HER-2-negative breast cancer.

Lyu D et al.

Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu, 2022

Upfront Next Generation Sequencing in Non-Small Cell Lung Cancer.

Kuang S et al.

Current Oncology (toronto, Ont.), 2022

35877212 (PubMed )
Supplement: curroncol-29-00352-s001.zip › LUNGS1_16_june_2022_supplemental_2_variants_no_code.pdf

Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

Chevrier S et al.

International Journal of Molecular Medicine, 2022

35244186 (PubMed )
Supplement: Supplementary_Data2.xlsx › Feuil1

Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Ikeuchi H et al.

Oncogene, 2022

35304574 (PubMed )
Supplement: 41388_2022_2263_MOESM5_ESM.xlsx › Supplementary_Table_4

Systematic population-based identification of NTRK and RET fusion-positive thyroid cancers.

Eszlinger M et al.

European Thyroid Journal, 2022

Circulating Cell-Free DNA-Based Comprehensive Molecular Analysis of Biliary Tract Cancers Using Next-Generation Sequencing.

Csoma SL et al.

Cancers, 2022

Diverse responses to EGFR-TKIs in patients with concurrent germline and somatic EGFR mutations.

Wu Y et al.

Lung Cancer (amsterdam, Netherlands), 2021

Two cases of non-small cell lung cancer patients with somatic or germline EGFR R776H mutation.

Guo T et al.

Lung Cancer (amsterdam, Netherlands), 2021

Evaluation of the Mutation Profile via Next-Generation Sequencing in a Turkish Population With Non-small Cell Lung Cancer.

Kahraman Çetin N et al.

Balkan Medical Journal, 2021

Germline Predisposition to Pediatric Cancer, from Next Generation Sequencing to Medical Care.

Gargallo P et al.

Cancers, 2021

34771502 (PubMed )
Supplement: cancers-13-05339-s001.zip › cancers-1401869-supplementary.xlsx › supplementary_material3

R-Score: A New Parameter to Assess the Quality of Variants' Calls Assessed by NGS Using Liquid Biopsies.

Serna-Blasco R et al.

Biology, 2021

34681053 (PubMed )
Supplement: biology-10-00954-s001.zip › biology-1339819-supplementary.pdf

Structure-based classification predicts drug response in EGFR-mutant NSCLC.

Robichaux JP et al.

Nature, 2021

34526717 (PubMed )
Supplement: 41586_2021_3898_MOESM1_ESM.pdf
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."