Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.T854S
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EGFR

NM_005228.5:p.T854S

Associated Papers

An in-depth exploration of four heterogeneity structure-based EGFR mutation subgroups in Chinese non-small cell lung cancer.

Yu Y et al.

Bmc Pulmonary Medicine, 2025

40611150 (PubMed )
Supplement: 12890_2025_3774_MOESM1_ESM.xlsx › Sheet1

Resistance Mutation Profiles Associated with Current Treatments for Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer in the United States: A Systematic Literature Review.

Vadagam P et al.

Current Oncology (toronto, Ont.), 2025

40277748 (PubMed )
Supplement: curroncol-32-00191-s001.zip › curroncol-3409061-supplementary.pdf

Outcomes in non-small cell lung cancer with uncommon epidermal growth factor receptor L858 substitutions under first-line epidermal growth factor receptor tyrosine kinase inhibitors: A large real-world cohort study.

Shao Y et al.

Cancer Science, 2024

38932450 (PubMed )
Supplement: CAS-115-2751-s001.pdf

Structure-Guided Strategies of Targeted Therapies for Patients with EGFR-Mutant Non-Small Cell Lung Cancer.

Du Z et al.

Biomolecules, 2023

36830579 (PubMed )
Supplement: biomolecules-13-00210-s001.zip › biomolecules-2098784-supplementary.xlsx › Table_S2

ERBB family fusions are recurrent and actionable oncogenic targets across cancer types.

Schubert L et al.

Frontiers in Oncology, 2023

37168365 (PubMed )
Supplement: Table_3.xlsx › EGFR_mutations

Structure-based classification predicts drug response in EGFR-mutant NSCLC.

Robichaux JP et al.

Nature, 2021

34526717 (PubMed )
Supplement: 41586_2021_3898_MOESM1_ESM.pdf

Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Mack PC et al.

Cancer, 2020

Phase and context shape the function of composite oncogenic mutations.

Gorelick AN et al.

Nature, 2020

32461694 (PubMed )
Supplement: NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx › Table_S2._Composite_mutations

Evolution of oncogenic signatures of mutation hotspots in tyrosine kinases supports the atavistic hypothesis of cancer.

Chen W et al.

Scientific Reports, 2018

29844492 (PubMed )
Supplement: 41598_2018_26653_MOESM2_ESM.xlsx › Dataset_S1

Two rare exon 21 EGFR mutations in patients treated with gefitinib.

Mompradé E et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2013

Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer.

Wu JY et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

21531810 (PubMed )
Supplement: 10780432ccr103408-sup-ccr_10-3408_wu_t4.pdf

Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations.

Avizienyte E et al.

The Biochemical Journal, 2008

18588508 (PubMed )
Supplement: supplement_1.pdf
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."