Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
The helicase domain of human Dicer prevents RNAi-independent activation of antiviral and inflammatory pathways.
Baldaccini M et al.
The Embo Journal, 2024
Therapeutic strategies for C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia.
Hautbergue GM et al.
Current Opinion in Neurology, 2021
PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs.
Cesaro T et al.
Scientific Reports, 2021
Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice.
Pattamatta A et al.
Human Molecular Genetics, 2021
Glycogen synthase kinase (GSK)-3 and the double-strand RNA-dependent kinase, PKR: When two kinases for the common good turn bad.
Piazzi M et al.
Biochimica Et Biophysica Acta. Molecular Cell Research, 2020
Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis.
Vivarini ÁC et al.
Frontiers in Immunology, 2017
Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication.
Braggin JE et al.
Virology, 2016
dsRNA binding protein PACT/RAX in gene silencing, development and diseases.
Yong Y et al.
Frontiers in Biology, 2014
The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G₁ arrest.
Bennett RL et al.
Cell Cycle (georgetown, Tex.), 2012
Functional domains and the antiviral effect of the double-stranded RNA-dependent protein kinase PKR from Paralichthys olivaceus.
Zhu R et al.
Journal of Virology, 2008
Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK.
Dey M et al.
The Journal of Biological Chemistry, 2007
The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase.
Wang S et al.
The Journal of Biological Chemistry, 2006
Attenuated expression of interferon-induced protein kinase PKR in a simian cell devoid of type I interferons.
Park SH et al.
Molecules and Cells, 2006
Double-stranded RNA-dependent protein kinase is required for bone calcification in MC3T3-E1 cells in vitro.
Yoshida K et al.
Experimental Cell Research, 2005
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition.
Dey M et al.
Cell, 2005
Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.
Tinton SA et al.
The Biochemical Journal, 2005
The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).
Zhang X et al.
The Journal of Biological Chemistry, 2004
RNA binding and intramolecular interactions modulate the regulation of gene expression by nuclear factor 110.
Reichman TW et al.
Rna (new York, N.y.), 2003
A new double-stranded RNA-binding protein that interacts with PKR.
Coolidge CJ et al.
Nucleic Acids Research, 2000
JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization.
Yang M et al.
The Journal of Biological Chemistry, 1999
Mutations in the double-stranded RNA-activated protein kinase insert region that uncouple catalysis from eIF2alpha binding.
Cai R et al.
The Journal of Biological Chemistry, 1998
Interaction of the human protein kinase PKR with the mouse PKR homolog occurs via the N-terminal region of PKR and does not inactivate autophosphorylation activity of mouse PKR.
Rende-Fournier R et al.
Virology, 1997
Isolation of the interferon-inducible RNA-dependent protein kinase Pkr promoter and identification of a novel DNA element within the 5'-flanking region of human and mouse Pkr genes.
Kuhen KL et al.
Virology, 1997
Mechanism of interferon action. Biochemical and genetic evidence for the intermolecular association of the RNA-dependent protein kinase PKR from human cells.
Ortega LG et al.
Virology, 1996
Mechanism of interferon action: RNA-binding activity of full-length and R-domain forms of the RNA-dependent protein kinase PKR--determination of KD values for VAI and TAR RNAs.
McCormack SJ et al.
Virology, 1995
Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae.
Romano PR et al.
Molecular and Cellular Biology, 1995
Mechanism of interferon action: autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cells.
Thomis DC et al.
Proceedings of the National Academy of Sciences of the United States of America, 1992