Associated Papers
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2α phosphorylation.
Shanmugam R et al.
The Biochemical Journal, 2024
Domain II of the translation elongation factor eEF1A is required for Gcn2 kinase inhibition.
Ramesh R et al.
Febs Letters, 2020
General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae.
Yuan W et al.
The Journal of Biological Chemistry, 2017
Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells.
Lageix S et al.
Plos Genetics, 2014
Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.
Padyana AK et al.
The Journal of Biological Chemistry, 2005
Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast.
Magazinnik T et al.
Nucleic Acids Research, 2005
Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.
Garcia-Barrio M et al.
The Journal of Biological Chemistry, 2002
The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation.
Qiu H et al.
The Embo Journal, 2001
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain.
Dong J et al.
Molecular Cell, 2000
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