Associated Papers
Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Sharp SY et al.
Nature Communications, 2024
eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance.
Patil S et al.
Iscience, 2023
Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1.
Chalkiadaki K et al.
Brain : a Journal of Neurology, 2023
MTORC2 is a physiological hydrophobic motif kinase of S6 Kinase 1.
Majeed ST et al.
Biochimica Et Biophysica Acta. Molecular Cell Research, 2023
A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis.
Chen X et al.
Nature Communications, 2022
mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation.
Jana S et al.
Jci Insight, 2021
MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression.
Knight JRP et al.
Cancer Discovery, 2021
mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation.
Majeed ST et al.
Cell Cycle (georgetown, Tex.), 2021
A Highly Selective MNK Inhibitor Rescues Deficits Associated with Fragile X Syndrome in Mice.
Shukla T et al.
Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics, 2021
Eukaryotic translation initiation factors as promising targets in cancer therapy.
Hao P et al.
Cell Communication and Signaling : Ccs, 2020
Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1.
Batool A et al.
Molecular and Cellular Biochemistry, 2020
A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.
Matsui Y et al.
Acta Crystallographica. Section F, Structural Biology Communications, 2018
Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation.
Amorim IS et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2018
Eukaryotic translation initiation factors and cancer.
Ali MU et al.
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2017
Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.
Korneeva NL et al.
The Journal of Biological Chemistry, 2016
Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.
Gkogkas CG et al.
Cell Reports, 2014
MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.
Landon AL et al.
Nature Communications, 2014
Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
Gorentla BK et al.
Journal of Immunology (baltimore, Md. : 1950), 2013
Regulation of translation initiation in eukaryotes: mechanisms and biological targets.
Sonenberg N et al.
Cell, 2009
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).
Buxade M et al.
Frontiers in Bioscience : a Journal and Virtual Library, 2008
Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.
Scheper GC et al.
The Journal of Biological Chemistry, 2002
Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo.
McKendrick L et al.
European Journal of Biochemistry, 2001
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
Pyronnet S et al.
The Embo Journal, 1999