Varaico: Literature-Extracted Genetic Variants

Gene:EML4
Variant:p.E545K
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EML4

NM_019063.5:p.E545K

Associated Papers

A prospective, multicenter, comprehensive genomic profile signature study in patients with EGFR-mutant advanced non-small cell lung cancer at the first-line treatment failure of osimertinib.

Shi Y et al.

Signal Transduction and Targeted Therapy, 2025

41326340 (PubMed )
Supplement: 41392_2025_2481_MOESM1_ESM.docx

NGS-based liquid biopsy profiling identifies mechanisms of resistance to ALK inhibitors: a step toward personalized NSCLC treatment.

Sánchez-Herrero E et al.

Molecular Oncology, 2021

34058070 (PubMed )
Supplement: MOL2-15-2363-s001.docx

Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors.

Ducker GS et al.

Oncogene, 2014

PIK3CA mutation in Chinese patients with lung squamous cell carcinoma.

Yu J et al.

Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu, 2013

Patterns of DNA mutations and ALK rearrangement in resected node negative lung adenocarcinoma.

Yip PY et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2013

PIK3CA mutations in advanced cancers: characteristics and outcomes.

Janku F et al.

Oncotarget, 2012

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."