Associated Papers
Integrating evidence from protein domains to identify cancer driver mutations.
Ostroverkhova D et al.
Protein Science : a Publication of the Protein Society, 2026
Clonal hematopoiesis associates with prevalent and incident cardiometabolic disease in a cardiac catheterization cohort.
Regan JA et al.
Plos One, 2026
Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations.
Colin-Leitzinger C et al.
Human Genomics, 2025
Clonal hematopoiesis in apparent treatment-resistant hypertension, insights from multiple medical centers and community-based cohorts.
Lv C et al.
Nature Aging, 2025
IRF3-p300 axis controls global acetylation and mitotic progression.
Kim WJ et al.
Biochemical and Biophysical Research Communications, 2025
Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes.
Hiitola E et al.
Science Advances, 2025
Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgrounds.
Colin-Leitzinger C et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis.
Wen S et al.
Nature Genetics, 2025
Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis.
Liu R et al.
Cell Metabolism, 2025
Dysregulation of the p300/CBP histone acetyltransferases in human cancer.
Xu L et al.
Epigenomics, 2025
Clonal Hematopoiesis Associates with Prevalent and Incident Cardiometabolic Disease in High-Risk Individuals.
Regan JA et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis.
Zuriaga MA et al.
European Heart Journal, 2024
Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems.
Maddineni A et al.
Biorxiv : the Preprint Server for Biology, 2024
Tailoring a CRISPR/Cas-based Epigenome Editor for Programmable Chromatin Acylation and Decreased Cytotoxicity.
Goell J et al.
Biorxiv : the Preprint Server for Biology, 2024
MED1 IDR acetylation reorganizes the transcription preinitiation complex, rewires 3D chromatin interactions and reprograms gene expression.
Lin R et al.
Biorxiv : the Preprint Server for Biology, 2024
Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme.
Sosinsky A et al.
Nature Medicine, 2024
CRISPR/dCas9 Tools: Epigenetic Mechanism and Application in Gene Transcriptional Regulation.
Cai R et al.
International Journal of Molecular Sciences, 2023
Rare variant associations with plasma protein levels in the UK Biobank.
Dhindsa RS et al.
Nature, 2023
Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.
Yu Z et al.
The Journal of Clinical Investigation, 2023
Long-term longitudinal analysis of 4,187 participants reveals new insights into determinants of incident clonal hematopoiesis.
Uddin MM et al.
Medrxiv : the Preprint Server for Health Sciences, 2023
Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.
Sakthikumar S et al.
Veterinary and Comparative Oncology, 2023
Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1.
Sun Z et al.
Molecular Cell, 2023
Clonal hematopoiesis is associated with protection from Alzheimer's disease.
Bouzid H et al.
Nature Medicine, 2023
Experimental analysis of bladder cancer-associated mutations in EP300 identifies EP300-R1627W as a driver mutation.
Luo M et al.
Molecular Medicine (cambridge, Mass.), 2023
Molecular subclusters of follicular lymphoma: a report from the United Kingdom's Haematological Malignancy Research Network.
Crouch S et al.
Blood Advances, 2022
Cancer-driving mutations are enriched in genic regions intolerant to germline variation.
Vitsios D et al.
Science Advances, 2022
Diagnostic value of a comprehensive, urothelial carcinoma-specific next-generation sequencing panel in urine cytology and bladder tumor specimens.
Sun T et al.
Cancer Cytopathology, 2021
Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.
Li X et al.
Npj Precision Oncology, 2021
Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis.
Chignon A et al.
Iscience, 2021
Mutation patterns in recurrent and/or metastatic oropharyngeal squamous cell carcinomas in relation to human papillomavirus status.
Reder H et al.
Cancer Medicine, 2021
Comprehensive Study of Germline Mutations and Double-Hit Events in Esophageal Squamous Cell Cancer.
Zeng B et al.
Frontiers in Oncology, 2021
Deep Genomic Sequencing of Bladder Urothelial Carcinoma in Southern Chinese Patients: A Single-Center Study.
Li DY et al.
Frontiers in Oncology, 2021
Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
Bick AG et al.
Nature, 2020
The acetyltransferase p300 regulates NRF2 stability and localization.
Ganner A et al.
Biochemical and Biophysical Research Communications, 2020
Immunogenicity and Immune Silence in Human Cancer.
Yarmarkovich M et al.
Frontiers in Immunology, 2020
Regulation of alternative splicing by p300-mediated acetylation of splicing factors.
Siam A et al.
Rna (new York, N.y.), 2019
Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis.
Rubio K et al.
Nature Communications, 2019
DNA polymerase ι is acetylated in response to SN2 alkylating agents.
McIntyre J et al.
Scientific Reports, 2019
Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment.
Hu Z et al.
Nature Communications, 2019
CREBBP gene mutations are frequently detected in in situ follicular neoplasia.
Schmidt J et al.
Blood, 2018
Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication.
Ling H et al.
Cell Reports, 2018
[Clinical manifestations of erythrocyte membrane protein coding gene mutations in hereditary spherocytosis].
Sun XJ et al.
Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, 2018
Transcription factor dimerization activates the p300 acetyltransferase.
Ortega E et al.
Nature, 2018
p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.
Huang H et al.
Molecular Cell, 2018
Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas.
Salloum R et al.
Acta Neuropathologica Communications, 2017
Pan-urologic cancer genomic subtypes that transcend tissue of origin.
Chen F et al.
Nature Communications, 2017
A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.
Wang SP et al.
Molecular Cell, 2017