Varaico: Literature-Extracted Genetic Variants

Gene:EPHB2
Variant:p.K662R
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EPHB2

NM_017449.5:p.K662R

Associated Papers

EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1.

Irie F et al.

Nature Cell Biology, 2005

Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses.

Zisch AH et al.

Oncogene, 2000

A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A.

Dodelet VC et al.

The Journal of Biological Chemistry, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."