Varaico: Literature-Extracted Genetic Variants

Gene:EPHX1
Variant:p.Y113H
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EPHX1

NM_001136018.4:p.Y113H

Associated Papers

Pharmacogenetics of anti-seizure medications in Arab countries: a comprehensive review.

Magadmi R

Future Science Oa, 2025

Prevalence of Low EPHX1 Activity-Associated Genotypes in Himalayan Populations of India.

Rai D et al.

American Journal of Human Biology : the Official Journal of the Human Biology Council, 2025

Contrastive sequence signatures between the both sides of a recombination spot reveal an adaptation at PPARD locus from standing variation for pleiotropy since out-of-Africa dispersal.

Shou W et al.

Bmc Genomics, 2025

40307732 (PubMed )
Supplement: 12864_2025_11620_MOESM2_ESM.xlsx › TS5

The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.

Wang LY et al.

Innovation (cambridge (mass.)), 2025

39991480 (PubMed )
Supplement: mmc5.xlsx › Sheet1

EPHX1 and ERCC2 polymorphisms are associated with cisplatin-induced nephrotoxicity and prognosis in Thai cancer patients.

Ahmed S et al.

Plos One, 2025

The Association between EPHX1 Gene Polymorphisms and Lung Cancer among Jordanian People.

Alqudah TE et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2024

Genetic linkage analysis of head and neck cancer in a Spanish family.

Pérez-Sayáns M et al.

Oral Diseases, 2024

Natural History of Germline BRCA1 Mutated and BRCA Wild-type Triple-negative Breast Cancer.

Gardi N et al.

Cancer Research Communications, 2024

38315150 (PubMed )
Supplement: crc-23-0277-s13.xlsx › Sheet1

Whole exome sequencing identifies genetic markers of enterovirus susceptibility in East Asians.

Sung CC et al.

Frontiers in Microbiology, 2024

39234544 (PubMed )
Supplement: Data_Sheet_2.xlsx › worksheet

Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.

Zhang T et al.

Peerj, 2024

39465171 (PubMed )
Supplement: peerj-12-18360-s002.7z › drug-metabolizing_enzymes_and_transporter__DMET__microarray › markerlist.xlsx › markerlist.TXT

Association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis.

Zhou T et al.

Bmc Pulmonary Medicine, 2023

A real-life pilot study of the clinical application of pharmacogenomics testing on saliva in epilepsy.

Riva A et al.

Epilepsia Open, 2023

Influence of EPHX1 c.337 T>C and UGT2B7*2 genetic polymorphisms on the requirement of carbamazepine maintenance dose in persons with epilepsy (PWE) of Southern part of India: a cross-sectional genetic association study.

Venkatraman S et al.

Drug Metabolism and Personalized Therapy, 2023

Elucidation of Increased Cervical Cancer Risk Due to Polymorphisms in XRCC1 (R399Q and R194W), ERCC5 (D1104H), and NQO1 (P187S).

Das AP et al.

Reproductive Sciences (thousand Oaks, Calif.), 2023

EPHX1 and GSTP1 polymorphisms are associated with COPD risk: a systematic review and meta-analysis.

Yang Q et al.

Frontiers in Genetics, 2023

Oxidative stress-related genes (EPHX1 and MnSOD) polymorphism and risk of pre-eclampsia: a meta-analysis.

Zhao G et al.

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022

Predictive role of polymorphic variants of phase II drug metabolising enzyme in modulating toxicity in North Indian lung cancer patients undergoing chemotherapy.

Walia H et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2022

Genetic variants associated with severe cutaneous adverse drug reactions induced by carbamazepine.

Nakkam N et al.

British Journal of Clinical Pharmacology, 2022

Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on leukemia risk: An updated meta-analysis.

Zhao Y et al.

Frontiers in Genetics, 2022

36386807 (PubMed )
Supplement: Table1.DOCX

EPOXID HYDROLASE SINGLE GENE POLYMORPHISM (RS1051740) AND SEVERITY OF CHRONIC OBSTRUCTIVE DISEASE.

Antonova I et al.

Wiadomosci Lekarskie (warsaw, Poland : 1960), 2022

ABCB1 c.3435C > T and EPHX1 c.416A > G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic patients.

Zhang ML et al.

Gene, 2021

Genetic polymorphisms in the mEH gene in relation to tobacco smoking: role in lung cancer susceptibility and survival in north Indian patients with lung cancer undergoing platinum-based chemotherapy.

Walia HK et al.

Future Oncology (london, England), 2021

Individualized Proteogenomics Reveals the Mutational Landscape of Melanoma Patients in Response to Immunotherapy.

Schmitt M et al.

Cancers, 2021

34771574 (PubMed )
Supplement: cancers-13-05411-s001.zip › cancers-1421686_Table_S4.xlsx › Sheet_1

Associations of AHR, CYP1A1, EPHX1, and GSTP1 genetic polymorphisms with small-for-gestational-age infants.

Yan H et al.

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2021

Association of EPHX1 polymorphisms with plasma concentration of carbamazepine in epileptic patients: Systematic review and meta-analysis.

Hu T et al.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 2021

Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Kim B et al.

Translational and Clinical Pharmacology, 2021

34621706 (PubMed )
Supplement: tcp-29-135-s001.xls › tcp-29-135-s001

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.

Gautheron J et al.

Elife, 2021

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine.

Yip VLM et al.

British Journal of Clinical Pharmacology, 2021

Polymorphisms in xenobiotic metabolism-related genes in patients with hepatocellular carcinoma: a case-control study.

Ferreira GD et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2021

Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer.

Liu S et al.

Communications Biology, 2021

33907296 (PubMed )
Supplement: 42003_2021_2024_MOESM10_ESM.xlsx › Supplementary_Data_7

Association of microsomal epoxide hydrolase gene (fast genotype) with lung functions impairment in wood workers.

Taha MM et al.

Journal of Complementary & Integrative Medicine, 2021

Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters.

Iannaccone T et al.

Pharmaceuticals (basel, Switzerland), 2021

A synergetic effect of BARD1 mutations on tumorigenesis.

Li W et al.

Nature Communications, 2021

33623049 (PubMed )
Supplement: 41467_2021_21519_MOESM5_ESM.xlsx › sheet1

Pharmacogenomics with red cells: a model to study protein variants of drug transporter genes.

Flegel WA et al.

Vox Sanguinis, 2021

Personalized Medicine Using Cutting Edge Technologies for Genetic Epilepsies.

Garcia-Rosa S et al.

Current Neuropharmacology, 2021

Pediatric Acute Promyelocytic Leukemia: Epidemiology, Molecular Features, and Importance of GST-Theta 1 in Chemotherapy Response and Outcome.

Andrade FG et al.

Frontiers in Oncology, 2021

Umbrella Review on Associations Between Single Nucleotide Polymorphisms and Lung Cancer Risk.

Li X et al.

Frontiers in Molecular Biosciences, 2021

34540891 (PubMed )
Supplement: DataSheet1.zip › Data_Sheet_---Supplementary_Additional_file › Supplementary_Additional_file › Supplementary_Additional_file_S2.docx

The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease.

Gautheron J et al.

International Journal of Molecular Sciences, 2020

DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms.

Rahimian E et al.

Dna Repair, 2020

Whole‑exome sequencing identifies a novel mutation of SLC20A2 (c.C1849T) as a possible cause of hereditary multiple exostoses in a Chinese family.

Li Y et al.

Molecular Medicine Reports, 2020

32705272 (PubMed )
Supplement: Supplementary_Data1.xlsx › filter_by_duplicate

An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.

Chang WC et al.

Expert Opinion on Drug Metabolism & Toxicology, 2020

Genetic and clinical risk factors associated with phenytoin-induced cutaneous adverse drug reactions in Thai population.

Sukasem C et al.

Pharmacoepidemiology and Drug Safety, 2020

Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia.

Cacabelos R

International Journal of Molecular Sciences, 2020

Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer.

Li G et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2020

31969372 (PubMed )
Supplement: 10559965epi191281-sup-230715_3_supp_6000458_q3kstt.docx

Applying whole-genome sequencing in relation to phenotype and outcomes in siblings with cystic fibrosis.

Wilk MA et al.

Cold Spring Harbor Molecular Case Studies, 2020

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."