Varaico: Literature-Extracted Genetic Variants

Gene:EPHX1
Variant:p.H139R
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EPHX1

NM_001136018.4:p.H139R

Associated Papers

Pharmacogenetics of anti-seizure medications in Arab countries: a comprehensive review.

Magadmi R

Future Science Oa, 2025

Analysis of the Relationship Between CHRNA3/5 and EPHX1 Polymorphisms to Tobacco Intake and Development of Chronic Obstructive Pulmonary Disease (COPD).

Prudente Bartholo T et al.

Biomedicines, 2025

Decoding the Impact of Genetic Polymorphisms in Xenobiotic Metabolizing Enzymes and Ovarian Cancer: A Comprehensive Review.

Sistla HC et al.

Environmental and Molecular Mutagenesis, 2025

Prevalence of Low EPHX1 Activity-Associated Genotypes in Himalayan Populations of India.

Rai D et al.

American Journal of Human Biology : the Official Journal of the Human Biology Council, 2025

Proteogenomic Profiling of Treatment-Naïve Metastatic Malignant Melanoma.

Kuras M et al.

Cancers, 2025

40075679 (PubMed )
Supplement: cancers-17-00832-s001.zip › Table_S5._SAAVs.xlsx › Table_S5A

The Association between EPHX1 Gene Polymorphisms and Lung Cancer among Jordanian People.

Alqudah TE et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2024

Genetic polymorphisms of drug-metabolizing enzymes in older and newer anti-seizure medications.

D'Onofrio G et al.

Expert Opinion on Drug Metabolism & Toxicology, 2024

Genetic linkage analysis of head and neck cancer in a Spanish family.

Pérez-Sayáns M et al.

Oral Diseases, 2024

Placental efflux transporters and antiseizure or antidepressant medication use impact birth weight in MoBa cohort.

Hernandez MH et al.

Iscience, 2024

38455980 (PubMed )
Supplement: mmc1.pdf

Association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis.

Zhou T et al.

Bmc Pulmonary Medicine, 2023

Somatic mutations reveal hyperactive Notch signaling and racial disparities in prurigo nodularis.

Rajeh A et al.

Medrxiv : the Preprint Server for Health Sciences, 2023

37808834 (PubMed )
Supplement: media-2.xlsx › pnSomatic_supplement_tableS2

EPHX1 and GSTP1 polymorphisms are associated with COPD risk: a systematic review and meta-analysis.

Yang Q et al.

Frontiers in Genetics, 2023

Oxidative stress-related genes (EPHX1 and MnSOD) polymorphism and risk of pre-eclampsia: a meta-analysis.

Zhao G et al.

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022

Predictive role of polymorphic variants of phase II drug metabolising enzyme in modulating toxicity in North Indian lung cancer patients undergoing chemotherapy.

Walia H et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2022

ABCB1 c.3435C > T and EPHX1 c.416A > G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic patients.

Zhang ML et al.

Gene, 2021

Genetic polymorphisms in the mEH gene in relation to tobacco smoking: role in lung cancer susceptibility and survival in north Indian patients with lung cancer undergoing platinum-based chemotherapy.

Walia HK et al.

Future Oncology (london, England), 2021

Association of EPHX1 polymorphisms with plasma concentration of carbamazepine in epileptic patients: Systematic review and meta-analysis.

Hu T et al.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 2021

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.

Gautheron J et al.

Elife, 2021

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine.

Yip VLM et al.

British Journal of Clinical Pharmacology, 2021

Polymorphisms in xenobiotic metabolism-related genes in patients with hepatocellular carcinoma: a case-control study.

Ferreira GD et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2021

Targeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer.

Liu S et al.

Communications Biology, 2021

33907296 (PubMed )
Supplement: 42003_2021_2024_MOESM10_ESM.xlsx › Supplementary_Data_7

Association of microsomal epoxide hydrolase gene (fast genotype) with lung functions impairment in wood workers.

Taha MM et al.

Journal of Complementary & Integrative Medicine, 2021

Warfarin dosing algorithms: A systematic review.

Asiimwe IG et al.

British Journal of Clinical Pharmacology, 2021

33080066 (PubMed )
Supplement: BCP-87-1717-s001.docx

Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters.

Iannaccone T et al.

Pharmaceuticals (basel, Switzerland), 2021

Personalized Medicine Using Cutting Edge Technologies for Genetic Epilepsies.

Garcia-Rosa S et al.

Current Neuropharmacology, 2021

SCN1A Mutation-Beyond Dravet Syndrome: A Systematic Review and Narrative Synthesis.

Ding J et al.

Frontiers in Neurology, 2021

35002916 (PubMed )
Supplement: Data_Sheet_1.ZIP › ________ › duplicates__1147__.xls › duplicates_1147_

The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease.

Gautheron J et al.

International Journal of Molecular Sciences, 2020

An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.

Chang WC et al.

Expert Opinion on Drug Metabolism & Toxicology, 2020

Genetic and clinical risk factors associated with phenytoin-induced cutaneous adverse drug reactions in Thai population.

Sukasem C et al.

Pharmacoepidemiology and Drug Safety, 2020

Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia.

Cacabelos R

International Journal of Molecular Sciences, 2020

Cumulative Evidence for Associations between Genetic Variants and Risk of Esophageal Cancer.

Li G et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2020

31969372 (PubMed )
Supplement: 10559965epi191281-sup-230715_3_supp_6000458_q3kstt.docx

The Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico.

Martínez-Magaña JJ et al.

Frontiers in Pharmacology, 2020

Mutant Proteomics of Lung Adenocarcinomas Harboring Different EGFR Mutations.

Nishimura T et al.

Frontiers in Oncology, 2020

32983988 (PubMed )
Supplement: Data_Sheet_2.xlsx › AZ018

Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population.

Can Demirdöğen B et al.

Neuropsychiatric Disease and Treatment, 2020

Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta-analysis and genome-wide association studies.

Tian J et al.

Cancer Medicine, 2019

A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.

Berghuis B et al.

Epilepsia Open, 2019

Exploration of germline variants responsible for adverse events of crizotinib in anaplastic lymphoma kinase-positive non-small cell lung cancer by target-gene panel sequencing.

Mizugaki H et al.

Lung Cancer (amsterdam, Netherlands), 2019

Association of Activity Altering Genotypes - Tyr113His and His139Arg in Microsomal Epoxide Hydrolase Enzyme with Esophageal Squamous Cell Carcinoma.

Nabi S et al.

Nutrition and Cancer, 2019

Pharmacogenetics of hepatocellular carcinoma and cholangiocarcinoma.

Alonso-Peña M et al.

Cancer Drug Resistance (alhambra, Calif.), 2019

Genetic variation of acquired structural chromosomal aberrations.

Vodicka P et al.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 2018

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."