Varaico: Literature-Extracted Genetic Variants

Gene:EPHX2
Variant:p.K55R
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EPHX2

NM_001979.6:p.K55R

Associated Papers

CYP metabolic pathway related gene polymorphism increases the risk of embolic and atherothrombotic stroke and vulnerable carotid plaque in southeast China.

Shao M et al.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, 2023

A hypothesis-driven study to comprehensively investigate the association between genetic polymorphisms in EPHX2 gene and cardiovascular diseases: Findings from the UK Biobank.

Zhu X et al.

Gene, 2022

Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy.

Mota-Zamorano S et al.

Journal of Clinical Medicine, 2021

No impact of soluble epoxide hydrolase rs4149243, rs2234914 and rs751142 genetic variants on the development of type II diabetes and its hypertensive complication among Jordanian patients.

Khamees M et al.

International Journal of Clinical Practice, 2021

The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease.

Gautheron J et al.

International Journal of Molecular Sciences, 2020

Polymorphisms in vasoactive eicosanoid genes of kidney donors affect biopsy scores and clinical outcomes in renal transplantation.

Mota-Zamorano S et al.

Plos One, 2019

Association between the EPHX2 p.Lys55Arg polymorphism and prognosis following an acute coronary syndrome.

Oni-Orisan A et al.

Prostaglandins & Other Lipid Mediators, 2018

Association between the soluble epoxide hydrolase gene and preeclampsia.

Sari I et al.

Hypertension in Pregnancy, 2017

Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery.

Shuey MM et al.

Plos One, 2017

Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa.

Shih PB et al.

Molecular Psychiatry, 2016

Disrupting Dimerization Translocates Soluble Epoxide Hydrolase to Peroxisomes.

Nelson JW et al.

Plos One, 2016

Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: Possible interaction with genes involved in 20-HETE and EETs metabolism.

Tagetti A et al.

Prostaglandins & Other Lipid Mediators, 2015

The metabolism of lysophosphatidic acids by allelic variants of human soluble epoxide hydrolase.

Purba ER et al.

Drug Metabolism and Pharmacokinetics, 2015

A 3'-UTR Polymorphism in Soluble Epoxide Hydrolase Gene Is Associated with Acute Rejection in Renal Transplant Recipients.

Gervasini G et al.

Plos One, 2015

Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans.

Ramirez CE et al.

Prostaglandins & Other Lipid Mediators, 2014

Role of soluble epoxide hydrolase in age-related vascular cognitive decline.

Nelson JW et al.

Prostaglandins & Other Lipid Mediators, 2014

Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation.

Morisseau C et al.

Journal of Lipid Research, 2014

Variations in the human soluble epoxide hydrolase gene and recurrence of atrial fibrillation after catheter ablation.

Wutzler A et al.

International Journal of Cardiology, 2013

Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease.

Xu Y et al.

Pharmacogenetics and Genomics, 2011

In vivo activity of epoxide hydrolase according to sequence variation affects the progression of human IgA nephropathy.

Lee JP et al.

American Journal of Physiology. Renal Physiology, 2011

Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with forearm vasodilator responses in humans.

Lee CR et al.

Hypertension (dallas, Tex. : 1979), 2011

Haplotype analysis of the CYP2J2 gene associated with myocardial infarction in a Chinese Han population.

Jie Z et al.

Cell Biochemistry and Function, 2010

Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes.

Fava C et al.

Pharmacogenetics and Genomics, 2010

Variation in the human soluble epoxide hydrolase gene and risk of restenosis after percutaneous coronary intervention.

Kullmann S et al.

Bmc Cardiovascular Disorders, 2009

Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals.

Yamada Y et al.

Stroke, 2008

Protein quaternary structure and expression levels contribute to peroxisomal-targeting-sequence-1-mediated peroxisomal import of human soluble epoxide hydrolase.

Luo B et al.

Journal of Molecular Biology, 2008

Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study.

Burdon KP et al.

Diabetes & Vascular Disease Research, 2008

Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population.

Yamada Y et al.

Journal of Medical Genetics, 2008

Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population.

Zhang L et al.

Pharmacogenetics and Genomics, 2008

CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.

Lee CR et al.

Pharmacogenetics and Genomics, 2007

Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury.

Koerner IP et al.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2007

Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study.

Lee CR et al.

Human Molecular Genetics, 2006

The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke.

Fornage M et al.

Human Molecular Genetics, 2005

Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure.

Srivastava PK et al.

Archives of Biochemistry and Biophysics, 2004

Polymorphisms in human soluble epoxide hydrolase.

Przybyla-Zawislak BD et al.

Molecular Pharmacology, 2003

Association between CYP4A11 and EPHX2 genetic polymorphisms and chronic kidney disease progression in hypertensive patients.

Suárez-Santisteban MA et al.

Nefrologia, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."