Varaico: Literature-Extracted Genetic Variants

Gene:ERBB2
Variant:p.E542K
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ERBB2

NM_004448.4:p.E542K

Associated Papers

PIK3CA mutation in ER-negative and HER2-positive breast cancer with apocrine differentiation.

Nozaki F et al.

Breast Cancer (tokyo, Japan), 2026

A prospective, multicenter, comprehensive genomic profile signature study in patients with EGFR-mutant advanced non-small cell lung cancer at the first-line treatment failure of osimertinib.

Shi Y et al.

Signal Transduction and Targeted Therapy, 2025

41326340 (PubMed )
Supplement: 41392_2025_2481_MOESM1_ESM.docx

Apocrine carcinoma of the breast: distinctive metabolic reprogramming and high-frequency PIK3CA mutations revealed by molecular and immunohistochemical analysis.

Nakamura H et al.

Histopathology, 2025

MutationAssessor in cBioPortal.

Su Y et al.

Biorxiv : the Preprint Server for Biology, 2025

Identification of Somatic Genetic Variants in Superficial Vascular Malformations by Liquid Biopsy in a Cohort of 88 Patients from a French Hospital.

El Sissy FN et al.

Molecular Diagnosis & Therapy, 2025

Reporting of molecular test results from cell-free DNA analyses: expert consensus recommendations from the 2023 European Liquid Biopsy Society ctDNA Workshop.

de Jager VD et al.

Ebiomedicine, 2025

40121940 (PubMed )
Supplement: mmc4.docx

Molecular characteristics of advanced colorectal cancer and multi-hit PIK3CA mutations.

Yasin F et al.

The Oncologist, 2024

Targeted Sequencing of HER2-Positive Breast Cancer Mutations Revealed a Potential Association between PIK3CA and Trastuzumab Resistance.

Mekhamer AM et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2024

39611930 (PubMed )
Supplement: APJCP-25-4051-s001.pdf

Unveiling the role of PIK3R1 in cancer: A comprehensive review of regulatory signaling and therapeutic implications.

Gupta I et al.

Seminars in Cancer Biology, 2024

Association of ESR1 Germline Variants with TP53 Somatic Variants in Breast Tumors in a Genome-wide Study.

Tjader NP et al.

Cancer Research Communications, 2024

Variation Analysis in Premenopausal and Postmenopausal Breast Cancer Cases.

Erdogdu IH et al.

Journal of Personalized Medicine, 2024

Negative Hyperselection of Resistance Mutations for Panitumumab Maintenance in RAS Wild-Type Metastatic Colorectal Cancer (PanaMa Phase II Trial, AIO KRK 0212).

Stahler A et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

38289994 (PubMed )
Supplement: ccr-23-3023_supplementary_data_1_suppds1.pdf

Somatic Mutations in Latin American Breast Cancer Patients: A Systematic Review and Meta-Analysis.

Martínez-Nava GA et al.

Diagnostics (basel, Switzerland), 2024

The Study of PIK3CA Hotspot Mutations and Co-Occurring with EGFR, KRAS, and TP53 Mutations in Non-Small Cell Lung Cancer.

Zhang Y et al.

Oncotargets and Therapy, 2024

Mutational Landscape and In-Silico Analysis of TP53, PIK3CA, and PTEN in Patients with Breast Cancer from Khyber Pakhtunkhwa.

Ahmad H et al.

Acs Omega, 2023

Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in breast cancer among Indian population.

Kumar R et al.

Cancer Cell International, 2023

Frequency and mutational spectrum of PIK3CA gene mutations in breast cancer patients: Largest and first report from Lebanon.

Hamadeh LN et al.

Gene, 2023

Alpelisib and fulvestrant in PIK3CA-mutated hormone receptor-positive HER2-negative advanced breast cancer included in the French early access program.

Bello Roufai D et al.

Oncogene, 2023

Intertumor and intratumor heterogeneity of PIK3CA mutations in extramammary Paget's disease.

Kusaba Y et al.

The Journal of Dermatology, 2022

Use of Liquid Biopsy to Detect PIK3CA Mutation in Metastatic Breast Cancer.

Nakai M et al.

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi, 2022

Sensitive and robust liquid biopsy-based detection of PIK3CA mutations in hormone-receptor-positive metastatic breast cancer patients.

Suppan C et al.

British Journal of Cancer, 2022

The Yin and Yang of ERBB4: Tumor Suppressor and Oncoprotein.

Lucas LM et al.

Pharmacological Reviews, 2022

Circulating PIK3CA mutation detection at diagnosis in non-metastatic inflammatory breast cancer patients.

Allouchery V et al.

Scientific Reports, 2021

Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.

Jin N et al.

The Journal of Clinical Investigation, 2021

Oncomine™ Comprehensive Assay v3 vs. Oncomine™ Comprehensive Assay Plus.

Vestergaard LK et al.

Cancers, 2021

Next-generation sequencing-based identification of EGFR and NOTCH2 complementary mutations in non-small cell lung cancer.

Niu L et al.

Oncology Letters, 2021

Comprehensive molecular profiling of pulmonary pleomorphic carcinoma.

Nagano M et al.

Npj Precision Oncology, 2021

34158601 (PubMed )
Supplement: 41698_2021_201_MOESM2_ESM.xlsx › Supplementary_Table_1

Spectrum of PIK3CA/AKT mutations across molecular subtypes of triple-negative breast cancer.

Kumar S et al.

Breast Cancer Research and Treatment, 2021

PIK3CA somatic alterations in invasive breast cancers: different spectrum from Caucasians to Chinese detected by next generation sequencing.

Jia M et al.

Breast Cancer (tokyo, Japan), 2021

TERT promoter hotspot mutations and gene amplification in metaplastic breast cancer.

da Silva EM et al.

Npj Breast Cancer, 2021

33863915 (PubMed )
Supplement: 41523_2021_250_MOESM1_ESM.pdf

Mutation analysis using cell-free DNA for endocrine therapy in patients with HR+ metastatic breast cancer.

Sim SH et al.

Scientific Reports, 2021

A pilot study of next generation sequencing-liquid biopsy on cell-free DNA as a novel non-invasive diagnostic tool for Klippel-Trenaunay syndrome.

Palmieri M et al.

Vascular, 2021

Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project.

Lee Y et al.

Cancer Research and Treatment, 2021

Genetic mutation profile of Chinese HER2-positive breast cancers and genetic predictors of responses to Neoadjuvant anti-HER2 therapy.

Li K et al.

Breast Cancer Research and Treatment, 2020

Frequency and spectrum of PIK3CA somatic mutations in breast cancer.

Martínez-Sáez O et al.

Breast Cancer Research : Bcr, 2020

Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer.

Gini B et al.

Journal of Thoracic Disease, 2020

Antitumor activity and safety of sirolimus for solid tumors with PIK3CA mutations: A multicenter, open-label, prospective single-arm study (KM 02-01, KCSG UN17-16).

Byeon S et al.

Translational Cancer Research, 2020

Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification.

Van Bockstal MR et al.

Molecular Oncology, 2020

A Systematic Review of the Prevalence and Diagnostic Workup of PIK3CA Mutations in HR+/HER2- Metastatic Breast Cancer.

Anderson EJ et al.

International Journal of Breast Cancer, 2020

Incidence and PD-L1 Expression of MET 14 Skipping in Chinese Population: A Non-Selective NSCLC Cohort Study Using RNA-Based Sequencing.

Xu Z et al.

Oncotargets and Therapy, 2020

Genotyping of Circulating Tumor DNA Reveals the Clinically Actionable Mutation Landscape of Advanced Colorectal Cancer.

Cao W et al.

Molecular Cancer Therapeutics, 2019

Exon 9 Mutation of PIK3CA Associated With Poor Survival in Patients With Epstein-Barr Virus-associated Gastric Cancer.

Seo AN et al.

Anticancer Research, 2019

Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer.

Kaur P et al.

Scientific Reports, 2019

30728399 (PubMed )
Supplement: 41598_2018_37574_MOESM1_ESM.pdf

The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China.

Wu H et al.

Cancer Management and Research, 2019

Oncogenic driver mutations in Swiss never smoker patients with lung adenocarcinoma and correlation with clinicopathologic characteristics and outcome.

Grosse C et al.

Plos One, 2019

PIK3CA Mutations and Neoadjuvant Therapy Outcome in Patients with Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: A Sequential Analysis.

Seo Y et al.

Journal of Breast Cancer, 2018

PIK3CA mutation profiling in patients with breast cancer, using a highly sensitive detection system.

Shimoi T et al.

Cancer Science, 2018

29906308 (PubMed )
Supplement: CAS-109-2558-s004.docx

Neoadjuvant chemotherapy in breast cancer: a dose-dense schedule in real life and putative role of PIK3CA mutations.

Cocciolone V et al.

Oncotarget, 2018

Simultaneous identification of clinically relevant single nucleotide variants, copy number alterations and gene fusions in solid tumors by targeted next-generation sequencing.

Oliveira DM et al.

Oncotarget, 2018

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."