Varaico: Literature-Extracted Genetic Variants

Gene:ERBB2
Variant:p.K753E
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ERBB2

NM_004448.4:p.K753E

Associated Papers

HER2 mutation as an emerging target in advanced breast cancer.

Bon G et al.

Cancer Science, 2024

Response to Trastuzumab and Lapatinib in a Metastatic Colorectal Cancer Harboring HER2 Amplification and HER2 S310F Mutation.

Wang C et al.

Journal of the National Comprehensive Cancer Network : Jnccn, 2021

Targeting HER2 genomic alterations in non-small cell lung cancer.

Zeng J et al.

Journal of the National Cancer Center, 2021

Partial Response to Pyrotinib Plus Capecitabine in an Advanced Breast Cancer Patient with HER2 Amplification and R157W Mutation After Anti-HER2 Treatment: A Case Report and Literature Review.

Qu Y et al.

Oncotargets and Therapy, 2021

Oncogenic mutations within the β3-αC loop of EGFR/ERBB2/BRAF/MAP2K1 predict response to therapies.

Zhang B et al.

Molecular Genetics & Genomic Medicine, 2020

Systematic response of staurosporine scaffold-based inhibitors to drug-resistant cancer kinase mutations.

He Y

Archiv Der Pharmazie, 2020

Somatic Mutations in HER2 and Implications for Current Treatment Paradigms in HER2-Positive Breast Cancer.

Gaibar M et al.

Journal of Oncology, 2020

High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2.

Nagano M et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2018

Structural investigations on mechanism of lapatinib resistance caused by HER-2 mutants.

Verma S et al.

Plos One, 2018

Genomic alterations of ERBB receptors in cancer: clinical implications.

Mishra R et al.

Oncotarget, 2017

Clinical and pathological characterization of HER2 mutations in human breast cancer: a systematic review of the literature.

Petrelli F et al.

Breast Cancer Research and Treatment, 2017

Dual Characteristics of Novel HER2 Kinase Domain Mutations in Response to HER2-Targeted Therapies in Human Breast Cancer.

Zuo WJ et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2016

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."