Varaico: Literature-Extracted Genetic Variants

Gene:ERBB2
Variant:p.L755F
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ERBB2

NM_004448.4:p.L755F

Associated Papers

Recapitulating the adenoma-carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids.

Mizutani T et al.

Nature Cancer, 2024

39487295 (PubMed )
Supplement: 43018_2024_841_MOESM8_ESM.xlsx › Fig.4e

Optimal systemic treatment and real-world clinical application of ctDNA in patients with metastatic HER2-mutant lung cancer.

Liu SY et al.

European Journal of Cancer (oxford, England : 1990), 2024

The predictive role of ERBB2 point mutations in metastatic colorectal cancer: A systematic review.

Vaghi C et al.

Cancer Treatment Reviews, 2023

Targeted therapy for advanced salivary gland carcinoma based on molecular profiling: results from MyPathway, a phase IIa multiple basket study.

Kurzrock R et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2020

HER2 Exon 20 Insertion Mutations in Lung Adenocarcinoma: Case Series and Response to Pyrotinib.

Zhang X et al.

Frontiers in Oncology, 2020

Afatinib in patients with metastatic or recurrent HER2-mutant lung cancers: a retrospective international multicentre study.

Lai WV et al.

European Journal of Cancer (oxford, England : 1990), 2019

Heterogeneous mutation pattern in tumor tissue and circulating tumor DNA warrants parallel NGS panel testing.

Guo Q et al.

Molecular Cancer, 2018

30153823 (PubMed )
Supplement: 12943_2018_875_MOESM3_ESM.xlsx › Table_S2_ctDNA_Alterations

Outcomes of chemotherapies and HER2 directed therapies in advanced HER2-mutant lung cancers.

Eng J et al.

Lung Cancer (amsterdam, Netherlands), 2016

Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer.

Kloth M et al.

Gut, 2016

Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches.

Drilon A et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2015

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."