Varaico: Literature-Extracted Genetic Variants

Gene:ERBB2
Variant:p.E812K
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ERBB2

NM_004448.4:p.E812K

Associated Papers

High-throughput characterization of 5886 HER2 variants identifies 112 new in cellulo gain-of-function mutations.

Giacoletto CJ et al.

Genomics, 2025

New Gain-of-Function Mutations Prioritize Mechanisms of HER2 Activation.

Giacoletto CJ et al.

Medrxiv : the Preprint Server for Health Sciences, 2025

Somatic mutation detection and KRAS amplification in testicular germ cell tumors.

Cabral ERM et al.

Frontiers in Oncology, 2023

37007070 (PubMed )
Supplement: DataSheet_1.zip › Table_S2.XLSX › Planilha1

Characterization of driver mutations in Chinese non-small cell lung cancer patients using a novel targeted sequencing panel.

Zhao J et al.

Journal of Thoracic Disease, 2022

Poziotinib in non-small-cell lung cancer patients with HER2 exon 20 mutations: A pooled analysis of randomized clinical trials.

Wang BC et al.

Medicine, 2022

Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Brown AL et al.

Plos Computational Biology, 2019

31034466 (PubMed )
Supplement: pcbi.1006981.s010.xlsx › final_benchmark

Response to Afatinib in a Patient with Non-Small Cell Lung Cancer Harboring HER2 R896G Mutation: A Case Report.

Lin L et al.

Oncotargets and Therapy, 2019

StrandAdvantage test for early-line and advanced-stage treatment decisions in solid tumors.

Sen M et al.

Cancer Medicine, 2017

28371134 (PubMed )
Supplement: CAM4-6-883-s002.xlsx › S2B_CLIA_Samples

The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas.

Lim CH et al.

Oncotarget, 2016

27175599 (PubMed )
Supplement: oncotarget-07-39758-s002.xlsx › TableS1

Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.

Wong SQ et al.

British Journal of Cancer, 2015

25742471 (PubMed )
Supplement: bjc201580x7.xls › Supp_Table_3

EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation.

Trowe T et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."