Varaico: Literature-Extracted Genetic Variants

Gene:ERBB2
Variant:p.R868W
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ERBB2

NM_004448.4:p.R868W

Associated Papers

Integrating evidence from protein domains to identify cancer driver mutations.

Ostroverkhova D et al.

Protein Science : a Publication of the Protein Society, 2026

41556616 (PubMed )
Supplement: PRO-35-e70422-s002.xlsx › Table_S1

The GigaAssay: A combined high throughput and highly accurate platform for variant classification.

Giacoletto CJ et al.

New Biotechnology, 2025

High-throughput characterization of 5886 HER2 variants identifies 112 new in cellulo gain-of-function mutations.

Giacoletto CJ et al.

Genomics, 2025

New Gain-of-Function Mutations Prioritize Mechanisms of HER2 Activation.

Giacoletto CJ et al.

Medrxiv : the Preprint Server for Health Sciences, 2025

ERBB2-Mutant Gastrointestinal Tumors Represent Heterogeneous Molecular Biology, Particularly in Microsatellite Instability, Tumor Mutation Burden, and Co-Mutated Genes: An In Silico Study.

Uchida S et al.

Current Issues in Molecular Biology, 2023

37754252 (PubMed )
Supplement: cimb-45-00468-s001.zip › Table_S1.xlsx › Sheet1

ERBB family fusions are recurrent and actionable oncogenic targets across cancer types.

Schubert L et al.

Frontiers in Oncology, 2023

37168365 (PubMed )
Supplement: Table_4.xlsx › ERBB2_mutations

Precision Medicine in Metastatic Colorectal Cancer: Targeting ERBB2 (HER-2) Oncogene.

Torres-Jiménez J et al.

Cancers, 2022

Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis.

Hoefflin R et al.

Cancers, 2021

33800365 (PubMed )
Supplement: cancers-13-01151-s001.zip › Supplementary_Data_1.xlsx › S_Data_1

Clinicopathological characteristics and genetic analysis of pulmonary carcinoid tumors: A single-center retrospective cohort study and literature review.

Li X et al.

Oncology Letters, 2020

Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity.

Robichaux JP et al.

Cancer Cell, 2019

Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types.

Kumar RD et al.

Scientific Reports, 2017

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."