Varaico: Literature-Extracted Genetic Variants

Gene:ESR1
Variant:p.D351G
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ESR1

NM_000125.4:p.D351G

Associated Papers

Estrogen receptor mutations found in breast cancer metastases integrated with the molecular pharmacology of selective ER modulators.

Jordan VC et al.

Journal of the National Cancer Institute, 2015

Role of aspartate 351 in transactivation and active conformation of estrogen receptor alpha.

Kim JH et al.

Journal of Molecular Endocrinology, 2005

Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2.

Gehm BD et al.

The Journal of Steroid Biochemistry and Molecular Biology, 2004

Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid 351.

MacGregor Schafer J et al.

Cancer Research, 2000

Control of the estrogen-like actions of the tamoxifen-estrogen receptor complex by the surface amino acid at position 351.

Levenson AS et al.

The Journal of Steroid Biochemistry and Molecular Biology, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."