Varaico: Literature-Extracted Genetic Variants

Gene:ESR1
Variant:p.D538V
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ESR1

NM_000125.4:p.D538V

Associated Papers

Clinical Utility of Targeted Next-Generation Sequencing for Determining Human Epidermal Growth Factor Receptor 2 Status and Optimizing Targeted Therapy in Breast Cancer.

Hara Y et al.

World Journal of Oncology, 2025

Predictors of fulvestrant long-term benefit in hormone receptor-positive/HER2 negative advanced breast cancer.

Torrisi R et al.

Scientific Reports, 2022

Formation of a powerful capping motif corresponding to start of "helix 12" in agonist-bound estrogen receptor-alpha contributes to increased constitutive activity of the protein.

Skafar DF

Cell Biochemistry and Biophysics, 2000

Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation.

Yudt MR et al.

Biochemistry, 1999

Three-dimensional models of estrogen receptor ligand binding domain complexes, based on related crystal structures and mutational and structure-activity relationship data.

Wurtz JM et al.

Journal of Medicinal Chemistry, 1998

Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

Wrenn CK et al.

The Journal of Biological Chemistry, 1993

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."