Associated Papers
The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells.
Nusawardhana A et al.
Nature Communications, 2026
Chromatin remodeler Fun30 facilitates the relocation of persistent DNA double-strand breaks to the nuclear periphery.
Iqbal M et al.
Febs Letters, 2026
Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1.
Senoussi I et al.
Nature Communications, 2025
EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers.
Maric M et al.
Nature Communications, 2025
Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30.
Huang PC et al.
The Embo Journal, 2025
PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress.
Mashayekhi F et al.
Cell Reports, 2024
Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection.
Ceppi I et al.
Nature, 2024
PCAF promotes R-loop resolution via histone acetylation.
Lee SY et al.
Nucleic Acids Research, 2024
The MRE11-RAD50-NBS1 complex both starts and extends DNA end resection in mouse meiosis.
Kim S et al.
Biorxiv : the Preprint Server for Biology, 2024
EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells.
García-Rodríguez N et al.
Nucleic Acids Research, 2024
Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30.
Huang PC et al.
Biorxiv : the Preprint Server for Biology, 2024
EXO1 protects BRCA1-deficient cells against toxic DNA lesions.
van de Kooij B et al.
Molecular Cell, 2024
Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forks.
Zhao Y et al.
Nucleic Acids Research, 2023
Mitochondrial superoxide dismutase Sod2 suppresses nuclear genome instability during oxidative stress.
Gupta SV et al.
Genetics, 2023
A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene.
Gao Y et al.
Nature Communications, 2023
Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice.
Wang S et al.
Nucleic Acids Research, 2022
Modifiers of Somatic Repeat Instability in Mouse Models of Friedreich Ataxia and the Fragile X-Related Disorders: Implications for the Mechanism of Somatic Expansion in Huntington's Disease.
Zhao X et al.
Journal of Huntington's Disease, 2021
FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders.
Deshmukh AL et al.
Journal of Huntington's Disease, 2021
Molecular structures and mechanisms of DNA break processing in mouse meiosis.
Yamada S et al.
Genes & Development, 2020
Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins.
Morafraile EC et al.
Nucleic Acids Research, 2020
BLM has Contrary Effects on Repeat-Mediated Deletions, based on the Distance of DNA DSBs to a Repeat and Repeat Divergence.
Mendez-Dorantes C et al.
Cell Reports, 2020
Assembling the Human Resectosome on DNA Curtains.
Soniat MM et al.
Methods in Molecular Biology (clifton, N.j.), 2019
MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective.
Zhao X et al.
Plos Genetics, 2018
The MRX complex regulates Exo1 resection activity by altering DNA end structure.
Gobbini E et al.
The Embo Journal, 2018
Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners.
Goellner EM et al.
Nature Structural & Molecular Biology, 2018
Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions.
Sertic S et al.
Molecular Cell, 2018
Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway.
Kato N et al.
Cell Reports, 2017
Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.
Becker JR et al.
Plos Genetics, 2015
14-3-3 proteins restrain the Exo1 nuclease to prevent overresection.
Chen X et al.
The Journal of Biological Chemistry, 2015
Exo1 phosphorylation status controls the hydroxyurea sensitivity of cells lacking the Pol32 subunit of DNA polymerases delta and zeta.
Doerfler L et al.
Dna Repair, 2014
Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1.
Bregenhorn S et al.
Nucleic Acids Research, 2014
Hydrolytic function of Exo1 in mammalian mismatch repair.
Shao H et al.
Nucleic Acids Research, 2014
Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.
Tomimatsu N et al.
Nature Communications, 2014
The Saccharomyces cerevisiae Mlh1-Mlh3 heterodimer is an endonuclease that preferentially binds to Holliday junctions.
Ranjha L et al.
The Journal of Biological Chemistry, 2014
DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).
Zhou Y et al.
The Journal of Biological Chemistry, 2013
The structure of Escherichia coli ExoIX--implications for DNA binding and catalysis in flap endonucleases.
Anstey-Gilbert CS et al.
Nucleic Acids Research, 2013
The mechanism of nucleotide excision repair-mediated UV-induced mutagenesis in nonproliferating cells.
Kozmin SG et al.
Genetics, 2013
Noncanonical role of the 9-1-1 clamp in the error-free DNA damage tolerance pathway.
Karras GI et al.
Molecular Cell, 2013
Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents.
Izumchenko E et al.
Dna Repair, 2012
Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Orans J et al.
Cell, 2011
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
Nimonkar AV et al.
Genes & Development, 2011
Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks.
Liberti SE et al.
Dna Repair, 2011