Varaico: Literature-Extracted Genetic Variants

Gene:EZR
Variant:p.T567A
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EZR

NM_001111077.2:p.T567A

Associated Papers

CLIC5A binds to and stabilizes the open and active conformation of ezrin.

Rahman MM et al.

The Journal of Biological Chemistry, 2025

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation.

Wang S et al.

Biorxiv : the Preprint Server for Biology, 2025

Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling.

Giamundo G et al.

Elife, 2025

Heat shock protein family B member 1 facilitates ezrin activation to control cell migration in esophageal squamous cell carcinoma.

Xie YH et al.

The International Journal of Biochemistry & Cell Biology, 2019

Activated ezrin controls MISP levels to ensure correct NuMA polarization and spindle orientation.

Kschonsak YT et al.

Journal of Cell Science, 2018

Emerging relationship between CFTR, actin and tight junction organization in cystic fibrosis airway epithelium.

Castellani S et al.

Histology and Histopathology, 2017

Correctors of mutant CFTR enhance subcortical cAMP-PKA signaling through modulating ezrin phosphorylation and cytoskeleton organization.

Abbattiscianni AC et al.

Journal of Cell Science, 2016

Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis.

Chai J et al.

Journal of Hepatology, 2015

Identification of Ezrin-Radixin-Moesin proteins as novel regulators of pathogenic B-cell receptor signaling and tumor growth in diffuse large B-cell lymphoma.

Pore D et al.

Leukemia, 2015

The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin.

Epting D et al.

Development (cambridge, England), 2015

STRIPAK components determine mode of cancer cell migration and metastasis.

Madsen CD et al.

Nature Cell Biology, 2015

Nuclear import of β-dystroglycan is facilitated by ezrin-mediated cytoskeleton reorganization.

Vásquez-Limeta A et al.

Plos One, 2014

NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA/ROCK pathway.

Castellani S et al.

Laboratory Investigation; a Journal of Technical Methods and Pathology, 2012

Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma.

Ren L et al.

Cancer Research, 2012

Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cells.

Favia M et al.

Molecular Biology of the Cell, 2010

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.

ten Klooster JP et al.

Developmental Cell, 2009

Properties of an ezrin mutant defective in F-actin binding.

Saleh HS et al.

Journal of Molecular Biology, 2009

Phosphorylation of ezrin on threonine 567 produces a change in secretory phenotype and repolarizes the gastric parietal cell.

Zhou R et al.

Journal of Cell Science, 2005

Ezrin-dependent regulation of the actin cytoskeleton by beta-dystroglycan.

Spence HJ et al.

Human Molecular Genetics, 2004

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.

Yu Y et al.

Nature Medicine, 2004

Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.

Yang HS et al.

Molecular Cell, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."