Associated Papers
The Effects of Heparin Binding and Arg596 Mutations on the Conformation of Thrombin-Antithrombin Michaelis Complex, Revealed by Enhanced Sampling Molecular Dynamics Simulations.
Balogh G et al.
International Journal of Molecular Sciences, 2025
Inherited thrombophilia in a Han Chinese family caused by prothrombin Ile441Met mutation.
Wen SY et al.
Research and Practice in Thrombosis and Haemostasis, 2025
From Circulating Biomarkers to Polymorphic Variants: A Narrative Review of Challenges in Thrombophilia Evaluation.
Miceli G et al.
Journal of Clinical Medicine, 2025
Assessment of a next generation sequencing gene panel strategy in 133 patients with negative thrombophilia screening.
Suchon P et al.
Journal of Thrombosis and Haemostasis : Jth, 2025
Identification of Prothrombin Belgrade Variant in a Mexican-American Family with Recurrent Deep Vein Thrombosis.
Moura Coelho da Silva É et al.
Th Open : Companion Journal to Thrombosis and Haemostasis, 2025
The effects of pathogenic and likely pathogenic variants for inherited hemostasis disorders in 140 214 UK Biobank participants.
Stefanucci L et al.
Blood, 2023
Three Cases of Unprovoked Venous Thromboembolism with Prothrombin p.Arg596Gln Variant and a Literature Review of Antithrombin Resistance.
Tsuji A et al.
Internal Medicine (tokyo, Japan), 2023
Evolving Knowledge on Primary and Secondary Prevention of Venous Thromboembolism in Carriers of Hereditary Thrombophilia: A Narrative Review.
Campello E et al.
Seminars in Thrombosis and Hemostasis, 2022
Antithrombin Resistance Rescues Clotting Defect of Homozygous Prothrombin-Y510N Dysprothrombinemia.
Lu Y et al.
Thrombosis and Haemostasis, 2022
Genetic risk factors for venous thromboembolism.
Zöller B et al.
Expert Review of Hematology, 2020
Linkage analysis combined with whole-exome sequencing identifies a novel prothrombin (F2) gene mutation in a Dutch Caucasian family with unexplained thrombosis.
Mulder R et al.
Haematologica, 2020
A Novel Heterozygous Variant in F2 Gene in a Chinese Patient With Coronary Thrombosis and Acute Myocardial Infarction Leads to Antithrombin Resistance.
Tang Y et al.
Frontiers in Genetics, 2020
New data on FII, FV, FIX and thrombomodulin defects: blood keeps clotting in normal and in peculiar ways.
Girolami A et al.
Hematology (amsterdam, Netherlands), 2019
Thrombophilia, risk factors and prevention.
Campello E et al.
Expert Review of Hematology, 2019
A paradoxical thrombogenic mutation in factor II at the target site of arthropod bleeding toxin.
Takenouchi T et al.
European Journal of Medical Genetics, 2019
Vitamin K-Dependent Coagulation Factors That May be Responsible for Both Bleeding and Thrombosis (FII, FVII, and FIX).
Girolami A et al.
Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/hemostasis, 2018
Prothrombin: Another Clotting Factor After FV That Is Involved Both in Bleeding and Thrombosis.
Girolami A et al.
Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/hemostasis, 2018
Screening and functional exploration of prothrombin Arg596 related mutations in Chinese venous thromboembolism patients.
Wu X et al.
Journal of Clinical Pathology, 2018
"In vitro" correction of the severe factor V deficiency-related coagulopathy by a novel plasma-derived factor V concentrate.
Bulato C et al.
Haemophilia : the Official Journal of the World Federation of Hemophilia, 2018
Structure-function studies of prothrombin Amrita, a dysfunctional prothrombin characterized by point mutation at Arg553 → Gln.
Melge AR et al.
International Journal of Biological Macromolecules, 2018
Congenital prothrombin defects: they are not only associated with bleeding but also with thrombosis: a new classification is needed.
Girolami A et al.
Hematology (amsterdam, Netherlands), 2018
In vitro exploration of latent prothrombin mutants conveying antithrombin resistance.
Tamura S et al.
Thrombosis Research, 2017
New clotting disorders that cast new light on blood coagulation and may play a role in clinical practice.
Girolami A et al.
Journal of Thrombosis and Thrombolysis, 2017
Clinical and biochemical characterization of the prothrombin Belgrade mutation in a large Serbian pedigree: new insights into the antithrombin resistance mechanism.
Miljic P et al.
Journal of Thrombosis and Haemostasis : Jth, 2017
Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation.
Ding Q et al.
Thrombosis and Haemostasis, 2017
Missense mutations in the gene encoding prothrombin corresponding to Arg596 cause antithrombin resistance and thrombomodulin resistance.
Takagi Y et al.
Thrombosis and Haemostasis, 2016
New Prothrombin Mutation (Arg596Trp, Prothrombin Padua 2) Associated With Venous Thromboembolism.
Bulato C et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2016
Family of melanocortin receptor (MCR) genes in mammals-mutations, polymorphisms and phenotypic effects.
Switonski M et al.
Journal of Applied Genetics, 2013