Associated Papers
The Effects of Heparin Binding and Arg596 Mutations on the Conformation of Thrombin-Antithrombin Michaelis Complex, Revealed by Enhanced Sampling Molecular Dynamics Simulations.
Balogh G et al.
International Journal of Molecular Sciences, 2025
Inherited thrombophilia in a Han Chinese family caused by prothrombin Ile441Met mutation.
Wen SY et al.
Research and Practice in Thrombosis and Haemostasis, 2025
From Circulating Biomarkers to Polymorphic Variants: A Narrative Review of Challenges in Thrombophilia Evaluation.
Miceli G et al.
Journal of Clinical Medicine, 2025
Whole genome sequencing identifies pathogenic genetic variants in Han Chinese patients with familial venous thromboembolism.
Zhang Z et al.
Communications Biology, 2025
Systemic thrombosis with prothrombin Belgrade mutation in a Chinese patient: A case report.
Wu YF et al.
World Journal of Clinical Cases, 2025
Assessment of a next generation sequencing gene panel strategy in 133 patients with negative thrombophilia screening.
Suchon P et al.
Journal of Thrombosis and Haemostasis : Jth, 2025
Heterozygous Prothrombin Mutation-Associated Thrombophilia.
Wu X et al.
Thrombosis and Haemostasis, 2025
Identification of Prothrombin Belgrade Variant in a Mexican-American Family with Recurrent Deep Vein Thrombosis.
Moura Coelho da Silva É et al.
Th Open : Companion Journal to Thrombosis and Haemostasis, 2025
The genetic risk factors for cerebral venous thrombosis: a case-control study in a Chinese national comprehensive hospital.
Wang S et al.
Thrombosis Journal, 2024
Effect of prothrombin Belgrade mutation, causing antithrombin resistance, on fibrin clot properties.
Dunjic Manevski S et al.
International Journal of Laboratory Hematology, 2024
Evaluation of prothrombotic risk of two PROC hotspot mutations (Arg189Trp and Lys193del) in Chinese population: a retrospective study.
Li L et al.
Thrombosis Journal, 2023
Monogenic Causes in Familial Stroke Across Intracerebral Hemorrhage and Ischemic Stroke Subtypes Identified by Whole-Exome Sequencing.
Chang LH et al.
Cellular and Molecular Neurobiology, 2023
Three Cases of Unprovoked Venous Thromboembolism with Prothrombin p.Arg596Gln Variant and a Literature Review of Antithrombin Resistance.
Tsuji A et al.
Internal Medicine (tokyo, Japan), 2023
A phenotype driven integrative framework uncovers molecular mechanisms of a rare hereditary thrombophilia.
Malod-Dognin N et al.
Plos One, 2023
Evolving Knowledge on Primary and Secondary Prevention of Venous Thromboembolism in Carriers of Hereditary Thrombophilia: A Narrative Review.
Campello E et al.
Seminars in Thrombosis and Hemostasis, 2022
Genetic risk factors for venous thromboembolism.
Zöller B et al.
Expert Review of Hematology, 2020
A Novel Heterozygous Variant in F2 Gene in a Chinese Patient With Coronary Thrombosis and Acute Myocardial Infarction Leads to Antithrombin Resistance.
Tang Y et al.
Frontiers in Genetics, 2020
New data on FII, FV, FIX and thrombomodulin defects: blood keeps clotting in normal and in peculiar ways.
Girolami A et al.
Hematology (amsterdam, Netherlands), 2019
Thrombophilia, risk factors and prevention.
Campello E et al.
Expert Review of Hematology, 2019
A paradoxical thrombogenic mutation in factor II at the target site of arthropod bleeding toxin.
Takenouchi T et al.
European Journal of Medical Genetics, 2019
Vitamin K-Dependent Coagulation Factors That May be Responsible for Both Bleeding and Thrombosis (FII, FVII, and FIX).
Girolami A et al.
Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/hemostasis, 2018
Prothrombin: Another Clotting Factor After FV That Is Involved Both in Bleeding and Thrombosis.
Girolami A et al.
Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/hemostasis, 2018
Screening and functional exploration of prothrombin Arg596 related mutations in Chinese venous thromboembolism patients.
Wu X et al.
Journal of Clinical Pathology, 2018
Familial pulmonary thromboembolism with a prothrombin mutation and antithrombin resistance.
Yoshida R et al.
Journal of Cardiology Cases, 2018
Structure-function studies of prothrombin Amrita, a dysfunctional prothrombin characterized by point mutation at Arg553 → Gln.
Melge AR et al.
International Journal of Biological Macromolecules, 2018
Congenital prothrombin defects: they are not only associated with bleeding but also with thrombosis: a new classification is needed.
Girolami A et al.
Hematology (amsterdam, Netherlands), 2018
In vitro exploration of latent prothrombin mutants conveying antithrombin resistance.
Tamura S et al.
Thrombosis Research, 2017
New clotting disorders that cast new light on blood coagulation and may play a role in clinical practice.
Girolami A et al.
Journal of Thrombosis and Thrombolysis, 2017
Clinical and biochemical characterization of the prothrombin Belgrade mutation in a large Serbian pedigree: new insights into the antithrombin resistance mechanism.
Miljic P et al.
Journal of Thrombosis and Haemostasis : Jth, 2017
Missense mutations in the gene encoding prothrombin corresponding to Arg596 cause antithrombin resistance and thrombomodulin resistance.
Takagi Y et al.
Thrombosis and Haemostasis, 2016
New Prothrombin Mutation (Arg596Trp, Prothrombin Padua 2) Associated With Venous Thromboembolism.
Bulato C et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2016
The first case of antithrombin-resistant prothrombin Belgrade mutation in Japanese.
Kishimoto M et al.
Annals of Hematology, 2016
Prothrombin 3'end gene variants in isolated pulmonary embolism--the first report of FIIc.*64_*66del and FIIc.*303T>C variants.
Gvozdenov M et al.
Acta Cardiologica, 2015
High prophylactic LMWH dose successfully suppressed hemostatic activation in pregnant woman with a new prothrombin c.1787G>A mutation.
Kovac M et al.
Thrombosis Research, 2015
Antithrombin-resistant prothrombin Yukuhashi mutation also causes thrombomodulin resistance in fibrinogen clotting but not in protein C activation.
Takagi Y et al.
Thrombosis Research, 2014
[Discovery and prospects of a novel thrombophilia: antithrombin resistance].
Takagi Y et al.
Nihon Rinsho. Japanese Journal of Clinical Medicine, 2014
A novel prothrombin mutation in two families with prominent thrombophilia--the first cases of antithrombin resistance in a Caucasian population.
Djordjevic V et al.
Journal of Thrombosis and Haemostasis : Jth, 2013
[The effect of FII c.1787G>A (prothrombin Belgrade) mutation on prothrombin gene expression in vitro].
Gvozdenov M et al.
Molekuliarnaia Biologiia, 0