Associated Papers
Genetic and nongenetic drivers of platelet reactivity in healthy Tanzanian individuals.
Kullaya VI et al.
Journal of Thrombosis and Haemostasis : Jth, 2024
The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes.
Denorme F et al.
The Journal of Clinical Investigation, 2023
Platelet protease activated receptor 4 (PAR 4) receptor genotype is associated with an increased risk of preterm birth.
Boelig RC et al.
Journal of Thrombosis and Haemostasis : Jth, 2022
The PAR4 Platelet Thrombin Receptor Variant rs773902 does not Impact the Incidence of Thrombotic or Bleeding Events in a Healthy Older Population.
Selvadurai MV et al.
Thrombosis and Haemostasis, 2022
Independent COL5A1 Variants in Cats with Ehlers-Danlos Syndrome.
Kiener S et al.
Genes, 2022
35627182 (PubMed )
Supplement: genes-13-00797-s001.zip › Table_S4_Private_Variants.xlsx › priv.het.prot.chang.var._case_4
G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1.
Downes K et al.
Blood Advances, 2022
Determination of PAR4 numbers on the surface of human platelets: no effect of the single nucleotide polymorphism rs773902.
Li S et al.
Platelets, 2021
PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153.
Han X et al.
Blood, 2020
The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition.
Whitley MJ et al.
Journal of Thrombosis and Haemostasis : Jth, 2018
Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers.
Wolff RK et al.
Genes, Chromosomes & Cancer, 2018
29575536 (PubMed )
Supplement: GCC-57-366-s004.xlsx › MSI
Protease-activated receptor-4 (PAR4) variant influences on platelet reactivity induced by PAR4-activating peptide through altered Ca2+ mobilization and ERK phosphorylation in healthy Japanese subjects.
Morikawa Y et al.
Thrombosis Research, 2018
Protease-Activated Receptor 4 Variant p.Tyr157Cys Reduces Platelet Functional Responses and Alters Receptor Trafficking.
Norman JE et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2016
Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race.
Edelstein LC et al.
Blood, 2014
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