Associated Papers
Dynamics of Fanconi anemia protein D2 in association with nuclear lipid droplet formation.
Hotani T et al.
Journal of Cell Science, 2025
The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination-Deficient Tumors.
Cadzow L et al.
Cancer Research, 2024
The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks.
van de Kooij B et al.
Nature Communications, 2024
Deciphering the role of post-translational modifications in fanconi anemia proteins and their influence on tumorigenesis.
Ma R et al.
Cancer Gene Therapy, 2024
The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export.
Olazabal-Herrero A et al.
Cell Reports, 2024
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress.
Brunner A et al.
Molecular Cell, 2023
Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development.
Bona N et al.
Nature Structural & Molecular Biology, 2023
FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability.
Liu W et al.
Nucleic Acids Research, 2023
MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway.
Luzwick JW et al.
Science Advances, 2021
Cyclin-Dependent Kinase-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity.
Cantres-Velez JA et al.
Molecular and Cellular Biology, 2021
TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response.
Ma C et al.
Aging, 2020
Emerging functions of Fanconi anemia genes in replication fork protection pathways.
Kolinjivadi AM et al.
Human Molecular Genetics, 2020
A distinct role for recombination repair factors in an early cellular response to transcription-replication conflicts.
Shao X et al.
Nucleic Acids Research, 2020
Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays.
Tan W et al.
Elife, 2020
Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway.
Xu M et al.
Science Advances, 2019
FANCD2 Binding to H4K20me2 via a Methyl-Binding Domain Is Essential for Efficient DNA Cross-Link Repair.
Paquin KL et al.
Molecular and Cellular Biology, 2019
Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination.
Liang Z et al.
Cell Reports, 2019
A new look at molecular biology of breast cancer.
Ma C et al.
Cancer Biology & Therapy, 2019
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery.
Tonzi P et al.
Elife, 2018
Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.
Motnenko A et al.
Plos Genetics, 2018
Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1.
Arkinson C et al.
Life Science Alliance, 2018
Constitutive role of the Fanconi anemia D2 gene in the replication stress response.
Tian Y et al.
The Journal of Biological Chemistry, 2017
Activation of the FA pathway mediated by phosphorylation and ubiquitination.
Ishiai M et al.
Mutation Research, 2017
Involvement of FANCD2 in Energy Metabolism via ATP5α.
Jayabal P et al.
Scientific Reports, 2017
Ubiquitination-Linked Phosphorylation of the FANCI S/TQ Cluster Contributes to Activation of the Fanconi Anemia I/D2 Complex.
Cheung RS et al.
Cell Reports, 2017
Coordination of the recruitment of the FANCD2 and PALB2 Fanconi anemia proteins by an ubiquitin signaling network.
Bick G et al.
Chromosoma, 2017
FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5'-DNA end.
Sato K et al.
Nucleic Acids Research, 2016
FANCD2 Facilitates Replication through Common Fragile Sites.
Madireddy A et al.
Molecular Cell, 2016
Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.
Alavattam KG et al.
Cell Reports, 2016
FANCD2 limits BLM-dependent telomere instability in the alternative lengthening of telomeres pathway.
Root H et al.
Human Molecular Genetics, 2016
Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway.
Lopez-Martinez D et al.
Cellular and Molecular Life Sciences : Cmls, 2016
The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2.
Liang CC et al.
Nature Communications, 2016
FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.
Kais Z et al.
Cell Reports, 2016
Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.
Michl J et al.
The Embo Journal, 2016
Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.
Thongthip S et al.
Genes & Development, 2016
Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells.
Renaud E et al.
Nucleic Acids Research, 2016
A novel role for non-ubiquitinated FANCD2 in response to hydroxyurea-induced DNA damage.
Chen X et al.
Oncogene, 2016
Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.
Federico MB et al.
Plos Genetics, 2016
Update of the human and mouse Fanconi anemia genes.
Dong H et al.
Human Genomics, 2015
FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2.
Castella M et al.
Plos Genetics, 2015
FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress.
Yang Y et al.
Nucleic Acids Research, 2015
ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress.
Chen YH et al.
Molecular Cell, 2015