Associated Papers
Deciphering the role of post-translational modifications in fanconi anemia proteins and their influence on tumorigenesis.
Ma R et al.
Cancer Gene Therapy, 2024
Mechanism, specificity, and function of FANCD2-FANCI ubiquitination and deubiquitination.
Lemonidis K et al.
The Febs Journal, 2022
FANCI functions as a repair/apoptosis switch in response to DNA crosslinks.
Shah RB et al.
Developmental Cell, 2021
Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays.
Tan W et al.
Elife, 2020
Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1.
Arkinson C et al.
Life Science Alliance, 2018
Activation of the FA pathway mediated by phosphorylation and ubiquitination.
Ishiai M et al.
Mutation Research, 2017
Ubiquitination-Linked Phosphorylation of the FANCI S/TQ Cluster Contributes to Activation of the Fanconi Anemia I/D2 Complex.
Cheung RS et al.
Cell Reports, 2017
FANCD2 Facilitates Replication through Common Fragile Sites.
Madireddy A et al.
Molecular Cell, 2016
Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.
Michl J et al.
The Embo Journal, 2016
FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2.
Castella M et al.
Plos Genetics, 2015
ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress.
Chen YH et al.
Molecular Cell, 2015
Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA.
Longerich S et al.
Nucleic Acids Research, 2014
Regulation of the Fanconi anemia pathway by a SUMO-like delivery network.
Yang K et al.
Genes & Development, 2011
Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair.
Colnaghi L et al.
Blood, 2011
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair.
Liu T et al.
Science (new York, N.y.), 2010
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.
Ishiai M et al.
Nature Structural & Molecular Biology, 2008
FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.
Sims AE et al.
Nature Structural & Molecular Biology, 2007
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
Smogorzewska A et al.
Cell, 2007
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