Varaico: Literature-Extracted Genetic Variants

Gene:FCGR2B
Variant:p.I232T
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FCGR2B

NM_001394477.1:p.I232T

Associated Papers

Genome-wide association studies reveal new insights into the genetic basis of IgG4-related disease in the Chinese Han population.

Yan S et al.

Annals of the Rheumatic Diseases, 2025

Germline Variants in the Immune Response-Related Genes: Possible Modifying Effect on Age-Dependent BRCA1 Penetrance in Breast Cancer Patient.

Kuligina ES et al.

Cancers, 2025

41374957 (PubMed )
Supplement: cancers-17-03756-s001.zip › Table_S4a.xlsx › Table_S4a

Large deletions in the F8 gene predict immune tolerance induction failure in people with severe hemophilia A.

Oomen I et al.

Research and Practice in Thrombosis and Haemostasis, 2025

Genetic variation of low-to-medium-affinity Fc-gamma receptors in Guillain-Barré syndrome.

van Tilburg SJ et al.

Journal of Neurology, 2025

FCGR2A-131R Is Associated with Lupus Nephritis Rather than Non-Lupus Nephritis SLE in an Indigenous African Caribbean Population.

Radouani F et al.

Current Issues in Molecular Biology, 2025

Fc gamma receptor polymorphisms in antibody therapy: implications for bioassay development to enhance product quality.

Twomey JD et al.

Antibody Therapeutics, 2025

Epidermal second-hit mutation in MVK gene associated with linear porokeratosis.

Zhao A et al.

Genes & Diseases, 2025

39386107 (PubMed )
Supplement: mmc3.xlsx › standard

Pharmacogenomic landscape of TNF inhibitors in the Middle Eastern Qatari population.

Jan Z et al.

Frontiers in Immunology, 2025

41346622 (PubMed )
Supplement: Table2.xlsx › Supplementary_Table_8

Fc gamma receptors: Their evolution, genomic architecture, genetic variation, and impact on human disease.

Frampton S et al.

Immunological Reviews, 2024

Immune Thrombocytopenia: Immune Dysregulation and Genetic Perturbations Deciphering the Fate of Platelets.

Tariq Z et al.

Frontiers in Bioscience (landmark Edition), 2024

Sequence variants influencing the regulation of serum IgG subclass levels.

Olafsdottir TA et al.

Nature Communications, 2024

39277589 (PubMed )
Supplement: 41467_2024_52470_MOESM4_ESM.xlsx › SD11

The Association between Genetics and Response to Treatment with Biologics in Patients with Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis, and Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis.

Al-Sofi RF et al.

International Journal of Molecular Sciences, 2024

38891983 (PubMed )
Supplement: ijms-25-05793-s001.zip › Supplementary_Table_S4.pdf

FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery aneurysms.

Uittenbogaard P et al.

Frontiers in Immunology, 2024

A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the 1q23 Gene Cluster Is Associated with Plasmodium falciparum Infection in Children Residing in Burkina Faso.

Cretin J et al.

International Journal of Molecular Sciences, 2023

Alterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy.

Gaynor N et al.

British Journal of Cancer, 2023

Role of lipid nanodomains for inhibitory FcγRIIb function.

Spiegel F et al.

Biorxiv : the Preprint Server for Biology, 2023

Comparative Analysis of FCGR Gene Polymorphism in Pulmonary Sarcoidosis and Tuberculosis.

Typiak M et al.

Cells, 2023

Genetic variations in low-to-medium-affinity Fcγ receptors and autoimmune neutropenia in early childhood in a Danish cohort.

Kløve-Mogensen K et al.

International Journal of Immunogenetics, 2023

LAG3 genotype of the donor and clinical outcome after allogeneic transplantation from HLA-identical sibling donors.

Cruz D et al.

Frontiers in Immunology, 2023

Genetic analysis and prenatal diagnosis of short-rib thoracic dysplasia 3 with or without polydactyly caused by compound heterozygous variants of DYNC2H1 gene in four Chinese families.

Fang Y et al.

Frontiers in Genetics, 2023

37007936 (PubMed )
Supplement: Table1.XLS › Sheet

Impaired B Cell Expression of the Inhibitory Fcγ Receptor IIB in Myasthenia Gravis.

Keller CW et al.

Annals of Neurology, 2022

Immunogenetics of Lupus Erythematosus.

Ünlü B et al.

Advances in Experimental Medicine and Biology, 2022

Single-nucleotide Fcγ receptor polymorphisms do not impact obinutuzumab/rituximab outcome in patients with lymphoma.

Strefford JC et al.

Blood Advances, 2021

Comprehensive Genomic and Transcriptomic Analysis of Three Synchronous Primary Tumours and a Recurrence from a Head and Neck Cancer Patient.

Bresadola L et al.

International Journal of Molecular Sciences, 2021

34299215 (PubMed )
Supplement: ijms-22-07583-s001.zip › SupplementaryTable3.xlsx › germline_mutations

Characterization of Rheumatoid Arthritis Risk-Associated SNPs and Identification of Novel Therapeutic Sites Using an In-Silico Approach.

Akhtar M et al.

Biology, 2021

Genetic biomarkers for intravenous immunoglobulin response in chronic inflammatory demyelinating polyradiculoneuropathy.

Kuitwaard K et al.

European Journal of Neurology, 2021

FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene.

Moraru M et al.

Frontiers in Immunology, 2021

The association and functional relevance of genetic variation in low-to-medium-affinity Fc-gamma receptors with clinical platelet transfusion refractoriness.

Nagelkerke SQ et al.

Journal of Thrombosis and Haemostasis : Jth, 2020

A FcɣRIIa polymorphism has a HLA-B57 and HLA-B27 independent effect on HIV disease outcome.

Carapito R et al.

Genes and Immunity, 2020

FcγR2B B2.4 haplotype predicts increased risk of red blood cell alloimmunization in sickle cell disease patients.

Costa Neto A et al.

Transfusion, 2020

Comments on and assessments of 'Associations between FCGR polymorphisms and immune thrombocytopenia: A meta-analysis'.

Gholami M et al.

Scandinavian Journal of Immunology, 2020

IgG4-related disease in the Japanese population: a genome-wide association study.

Terao C et al.

The Lancet. Rheumatology, 2019

Associations between FCGR polymorphisms and immune thrombocytopenia: A meta-analysis.

Li G et al.

Scandinavian Journal of Immunology, 2019

Impact of Human FcγR Gene Polymorphisms on IgG-Triggered Cytokine Release: Critical Importance of Cell Assay Format.

Hussain K et al.

Frontiers in Immunology, 2019

The Human FcγRII (CD32) Family of Leukocyte FcR in Health and Disease.

Anania JC et al.

Frontiers in Immunology, 2019

Extensive Ethnic Variation and Linkage Disequilibrium at the FCGR2/3 Locus: Different Genetic Associations Revealed in Kawasaki Disease.

Nagelkerke SQ et al.

Frontiers in Immunology, 2019

The Lupus-Associated Fcγ Receptor IIb-I232T Polymorphism Results in Impairment in the Negative Selection of Low-Affinity Germinal Center B Cells Via c-Abl in Mice.

Jhou JP et al.

Arthritis & Rheumatology (hoboken, N.j.), 2018

FC gamma receptor polymorphisms in patients with immune thrombocytopenia.

Pavkovic M et al.

Hematology (amsterdam, Netherlands), 2018

Discrimination of FCGR2B polymorphism without coamplification of FCGR2A and FCGR2C genes.

Bonatti F et al.

International Journal of Immunogenetics, 2018

Nonclassical FCGR2C haplotype is associated with protection from red blood cell alloimmunization in sickle cell disease.

Meinderts SM et al.

Blood, 2017

Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232.

Xu L et al.

The Journal of Experimental Medicine, 2016

Comprehensive Assessment of the Association between FCGRs polymorphisms and the risk of systemic lupus erythematosus: Evidence from a Meta-Analysis.

Zhu XW et al.

Scientific Reports, 2016

Fc-gamma receptor polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis.

Tsang-A-Sjoe MW et al.

Rheumatology (oxford, England), 2016

Variability at the FCGR locus: characterization in Black South Africans and evidence for ethnic variation in and out of Africa.

Lassaunière R et al.

Genes and Immunity, 2016

A Transmembrane Polymorphism of Fcγ Receptor IIb Is Associated with Kidney Deficiency Syndrome in Rheumatoid Arthritis.

Mo N et al.

Evidence-based Complementary and Alternative Medicine : Ecam, 2016

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."