Varaico: Literature-Extracted Genetic Variants

Gene:FECH
Variant:p.E343K
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FECH

NM_000140.5:p.E343K

Associated Papers

Investigation by MD simulation of the key residues related to substrate-binding and heme-release in human ferrochelatase.

Wang Y et al.

Journal of Molecular Modeling, 2013

Identification and characterization of solvent-filled channels in human ferrochelatase.

Medlock AE et al.

Biochemistry, 2012

A pi-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase.

Medlock AE et al.

Journal of Molecular Biology, 2007

Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis.

Dailey HA et al.

Biochemistry, 2007

Human ferrochelatase: characterization of substrate-iron binding and proton-abstracting residues.

Sellers VM et al.

Biochemistry, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."