Associated Papers
An ultrasensitive DNA-enhanced amplification method for detecting cfDNA drug-resistant mutations in non-small cell lung cancer with selective FEN-assisted degradation of dominant somatic fragments.
Zhang J et al.
Clinical Chemistry and Laboratory Medicine, 2025
Small-Molecule Inhibitors Targeting FEN1 for Cancer Therapy.
Yang F et al.
Biomolecules, 2022
Alternative end-joining in BCR gene rearrangements and translocations.
Bai W et al.
Acta Biochimica Et Biophysica Sinica, 2022
FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers.
Mesquita KA et al.
Cancers, 2021
Flap Endonuclease 1 Mutations A159V and E160D Cause Genomic Instability by Slowing Reaction on Double-Flap Substrates.
Algasaier SI et al.
Biochemistry, 2018
Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Xu H et al.
Nucleic Acids Research, 2018
Roles for the Rad27 Flap Endonuclease in Mitochondrial Mutagenesis and Double-Strand Break Repair in Saccharomyces cerevisiae.
Nagarajan P et al.
Genetics, 2017
Flap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
Sang Y et al.
Thoracic Cancer, 2017
The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation.
Sun H et al.
Oncogene, 2017
Flap endonuclease 1 polymorphisms (rs174538 and rs4246215) contribute to an increased cancer risk: Evidence from a meta-analysis.
Ren H et al.
Molecular and Clinical Oncology, 2015
Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex.
Liu S et al.
The Embo Journal, 2015
Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand.
Teasley DC et al.
The Journal of Biological Chemistry, 2015
The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.
Chung L et al.
Oncogene, 2015
Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.
Abdel-Fatah TM et al.
Molecular Oncology, 2014
The role of DNA exonucleases in protecting genome stability and their impact on ageing.
Mason PA et al.
Age (dordrecht, Netherlands), 2012
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression.
Zheng L et al.
Nature Communications, 2012
High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice.
Wu Z et al.
Mutation Research, 2012
Mapping the FEN1 interaction domain with hTERT.
Sampathi S et al.
Biochemical and Biophysical Research Communications, 2011
Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice.
Xu H et al.
Oncogene, 2011
Functional regulation of FEN1 nuclease and its link to cancer.
Zheng L et al.
Nucleic Acids Research, 2011
Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk.
Yang M et al.
Human Mutation, 2009
Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance.
Sampathi S et al.
The Journal of Biological Chemistry, 2009
Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.
Larsen E et al.
Cancer Research, 2008
Fen1 mutations result in autoimmunity, chronic inflammation and cancers.
Zheng L et al.
Nature Medicine, 2007
Human flap endonuclease-1: conformational change upon binding to the flap DNA substrate and location of the Mg2+ binding site.
Kim CY et al.
Biochemistry, 2001
Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability.
Greene AL et al.
Human Molecular Genetics, 1999
Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates.
Frank G et al.
The Journal of Biological Chemistry, 1998