Associated Papers
Flap endonuclease 1 repairs DNA-protein cross-links via ADP-ribosylation-dependent mechanisms.
Sun Y et al.
Science Advances, 2025
PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks by FEN1.
Saha LK et al.
Cell Reports, 2024
Small-Molecule Inhibitors Targeting FEN1 for Cancer Therapy.
Yang F et al.
Biomolecules, 2022
Modeling DNA trapping of anticancer therapeutic targets using missense mutations identifies dominant synthetic lethal interactions.
Hamza A et al.
Proceedings of the National Academy of Sciences of the United States of America, 2021
Structure of the processive human Pol δ holoenzyme.
Lancey C et al.
Nature Communications, 2020
Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Xu H et al.
Nucleic Acids Research, 2018
Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Tsutakawa SE et al.
Nature Communications, 2017
Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand.
Teasley DC et al.
The Journal of Biological Chemistry, 2015
Double strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamily.
Tsutakawa SE et al.
Mechanisms of Ageing and Development, 2012
Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.
Tsutakawa SE et al.
Cell, 2011
Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay.
Jinek M et al.
Molecular Cell, 2011
Repeat instability as the basis for human diseases and as a potential target for therapy.
López Castel A et al.
Nature Reviews. Molecular Cell Biology, 2010
Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion.
Liu Y et al.
The Journal of Biological Chemistry, 2009
Flap endonuclease 1 contributes to telomere stability.
Saharia A et al.
Current Biology : Cb, 2008
Interaction interface of human flap endonuclease-1 with its DNA substrates.
Qiu J et al.
The Journal of Biological Chemistry, 2004
Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability.
Spiro C et al.
Molecular and Cellular Biology, 2003
Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination.
Qiu J et al.
The Journal of Biological Chemistry, 2002
Defective flap endonuclease 1 activity in mammalian cells is associated with impaired DNA repair and prolonged S phase delay.
Shibata Y et al.
The Journal of Biological Chemistry, 2002
Human flap endonuclease-1: conformational change upon binding to the flap DNA substrate and location of the Mg2+ binding site.
Kim CY et al.
Biochemistry, 2001
Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability.
Greene AL et al.
Human Molecular Genetics, 1999
A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.
Gary R et al.
Molecular and Cellular Biology, 1999
Structural changes measured by X-ray scattering from human flap endonuclease-1 complexed with Mg2+ and flap DNA substrate.
Kim CY et al.
The Journal of Biological Chemistry, 1999
Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates.
Frank G et al.
The Journal of Biological Chemistry, 1998
Characterization of a putative helix-loop-helix motif in nucleotide excision repair endonuclease, XPG.
Park MS et al.
The Journal of Biological Chemistry, 1997
Functional analysis of point mutations in human flap endonuclease-1 active site.
Shen B et al.
Nucleic Acids Research, 1997
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1.
Shen B et al.
The Journal of Biological Chemistry, 1996