Varaico: Literature-Extracted Genetic Variants

Gene:FGFR1
Variant:p.Y654F
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FGFR1

NM_023110.3:p.Y654F

Associated Papers

Discriminating activating, deactivating and resistance variants in protein kinases.

Singh G et al.

Genome Medicine, 2025

41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S5

The crystal and cryo-EM structures of PLCγ2 reveal dynamic interdomain recognitions in autoinhibition.

Shin YC et al.

Science Advances, 2024

The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in Xenopus.

Zhang F et al.

Proceedings of the National Academy of Sciences of the United States of America, 2021

33975953 (PubMed )
Supplement: pnas.2100342118.sapp.pdf

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.

Liu Y et al.

Ebiomedicine, 2020

Nuclear magnetic resonance analysis of the conformational state of cancer mutant of fibroblast growth factor receptor 1 tyrosine kinase domain.

Kobashigawa Y et al.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2016

Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain.

Kobashigawa Y et al.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2015

Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation.

Bunney TD et al.

Structure (london, England : 1993), 2012

23063561 (PubMed )
Supplement: mmc1.pdf

Fibronectin induces endothelial cell migration through β1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766.

Zou L et al.

The Journal of Biological Chemistry, 2012

Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.

Persaud A et al.

The Embo Journal, 2011

21765395 (PubMed )
Supplement: 44318_2011_BFEMBJ2011234_MOESM1_ESM.pdf
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."