Associated Papers
Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations.
Tangermann C et al.
Nature Genetics, 2026
41361008 (PubMed )
Supplement: 41588_2025_2431_MOESM3_ESM.xlsx › S10_Screen_data_table
The crystal and cryo-EM structures of PLCγ2 reveal dynamic interdomain recognitions in autoinhibition.
Shin YC et al.
Science Advances, 2024
Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.
Liu Y et al.
Ebiomedicine, 2020
Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments.
Guo X et al.
Integrative Zoology, 2016
Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases.
Xu Q et al.
Science Signaling, 2015
Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology.
Belov AA et al.
Cold Spring Harbor Perspectives in Biology, 2013
Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation.
Bunney TD et al.
Structure (london, England : 1993), 2012
23063561 (PubMed )
Supplement: mmc1.pdf
Fibronectin induces endothelial cell migration through β1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766.
Zou L et al.
The Journal of Biological Chemistry, 2012
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Bae JH et al.
Cell, 2009
Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations.
Roumiantsev S et al.
Cancer Cell, 2004
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