Varaico: Literature-Extracted Genetic Variants

Gene:FGFR2
Variant:p.D651Y
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FGFR2

NM_001144913.1:p.D651Y

Associated Papers

Recurrent resistance mutations to lirafugratinib inform treatment sequencing in FGFR2-driven tumors.

Facchinetti F et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2026

Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations.

Tangermann C et al.

Nature Genetics, 2026

41361008 (PubMed )
Supplement: 41588_2025_2431_MOESM3_ESM.xlsx › S7_Reported_resistance

Understanding and Overcoming Resistance to Selective FGFR Inhibitors across FGFR2-Driven Malignancies.

Facchinetti F et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

Author Correction: Genetic features and therapeutic relevance of emergent circulating tumor DNA alterations in refractory non-colorectal gastrointestinal cancers.

Hsiehchen D et al.

Nature Communications, 2023

37993437 (PubMed )
Supplement: 41467_2023_43052_MOESM2_ESM.xlsx › Sup_Figure_5

Genetic features and therapeutic relevance of emergent circulating tumor DNA alterations in refractory non-colorectal gastrointestinal cancers.

Hsiehchen D et al.

Nature Communications, 2022

36463294 (PubMed )
Supplement: 41467_2022_35144_MOESM3_ESM.xlsx › Sup_Figure_5

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.

Zingg D et al.

Nature, 2022

35948633 (PubMed )
Supplement: 41586_2022_5066_MOESM16_ESM.xlsx › ED_Fig._2a

A Pancancer Analysis of the Expression Landscape and Clinical Relevance of Fibroblast Growth Factor Receptor 2 in Human Cancers.

Li J et al.

Frontiers in Oncology, 2021

33968743 (PubMed )
Supplement: Table_2.XLSX › table
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."