Varaico: Literature-Extracted Genetic Variants

Gene:FGFR2
Variant:p.L551F
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FGFR2

NM_001144913.1:p.L551F

Associated Papers

Recurrent resistance mutations to lirafugratinib inform treatment sequencing in FGFR2-driven tumors.

Facchinetti F et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2026

Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations.

Tangermann C et al.

Nature Genetics, 2026

41361008 (PubMed )
Supplement: 41588_2025_2431_MOESM3_ESM.xlsx › S7_Reported_resistance

Genomic correlates of response and resistance to the irreversible FGFR1-4 inhibitor futibatinib based on biopsy and circulating tumor DNA profiling.

Goyal L et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2025

Understanding and Overcoming Resistance to Selective FGFR Inhibitors across FGFR2-Driven Malignancies.

Facchinetti F et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer.

Facchinetti F et al.

Cancer Discovery, 2023

FGFR2 point mutation in 2 cases of pleomorphic adenoma progressing to myoepithelial carcinoma.

Pikul J et al.

Contemporary Oncology (poznan, Poland), 2023

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.

Zingg D et al.

Nature, 2022

35948633 (PubMed )
Supplement: 41586_2022_5066_MOESM16_ESM.xlsx › ED_Fig._2a
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