Varaico: Literature-Extracted Genetic Variants

Gene:FGFR2
Variant:p.N546K
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FGFR2

NM_000141.5:p.N546K

Associated Papers

Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations.

Tangermann C et al.

Nature Genetics, 2026

41361008 (PubMed )
Supplement: 41588_2025_2431_MOESM4_ESM.xlsx › Extended_data_figure_6a

A prospective, multicenter, comprehensive genomic profile signature study in patients with EGFR-mutant advanced non-small cell lung cancer at the first-line treatment failure of osimertinib.

Shi Y et al.

Signal Transduction and Targeted Therapy, 2025

41326340 (PubMed )
Supplement: 41392_2025_2481_MOESM1_ESM.docx

Expansion of the complex genotypic and phenotypic spectrum of FGFR2-associated neurocutaneous syndromes.

Schmidt J et al.

Human Genetics, 2024

Activating FGFR1 Mutations in Sporadic Pheochromocytomas.

Welander J et al.

World Journal of Surgery, 2018

Biophysical characterization of drug-resistant mutants of fibroblast growth factor receptor 1.

Yoza K et al.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2016

Nuclear magnetic resonance analysis of the conformational state of cancer mutant of fibroblast growth factor receptor 1 tyrosine kinase domain.

Kobashigawa Y et al.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2016

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."