Varaico: Literature-Extracted Genetic Variants

Gene:FGFR2
Variant:p.W4C
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FGFR2

NM_000141.5:p.W4C

Associated Papers

Recurrent resistance mutations to lirafugratinib inform treatment sequencing in FGFR2-driven tumors.

Facchinetti F et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2026

Oncogenic mutations of clinical significance in colorectal cancer.

Lea V et al.

Pathology, 2025

Inflammatory Giant Cell Carcinoma of the Lung: Clinicopathologic, Immunohistochemical, and Next-generation Sequencing Study of 14 Cases.

Suster DI et al.

The American Journal of Surgical Pathology, 2024

Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma.

Wu Q et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

Baseline mutational profiles of patients with carcinoma of unknown primary origin enrolled in the CUPISCO study.

Westphalen CB et al.

Esmo Open, 2023

37922692 (PubMed )
Supplement: mmc1.docx

ARID1A Mutation from Targeted Next-Generation Sequencing Predicts Primary Resistance to Gemcitabine and Cisplatin Chemotherapy in Advanced Biliary Tract Cancer.

Lee SH et al.

Cancer Research and Treatment, 2023

Molecular Characterization of Biliary Tract Cancer Predicts Chemotherapy and Programmed Death 1/Programmed Death-Ligand 1 Blockade Responses.

Yoon JG et al.

Hepatology (baltimore, Md.), 2021

FGFR2 Extracellular Domain In-Frame Deletions Are Therapeutically Targetable Genomic Alterations That Function as Oncogenic Drivers in Cholangiocarcinoma.

Cleary JM et al.

Cancer Discovery, 2021

Clinically significant genomic alterations in the Chinese and Western patients with intrahepatic cholangiocarcinoma.

Xu S et al.

Bmc Cancer, 2021

Clinicogenomic Analysis of FGFR2-Rearranged Cholangiocarcinoma Identifies Correlates of Response and Mechanisms of Resistance to Pemigatinib.

Silverman IM et al.

Cancer Discovery, 2021

Epidemiologic Features of NSCLC Gene Alterations in Hispanic Patients from Puerto Rico.

Zheng R et al.

Cancers, 2020

Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups.

Egan C et al.

Haematologica, 2020

Comprehensive genomic profile of cholangiocarcinomas in China.

Tian W et al.

Oncology Letters, 2020

Linear keratinocytic epidermal nevi on trunk skin caused by a somatic FGFR2 p.C382R mutation.

Tanaka R et al.

The Journal of Dermatology, 2018

A KRAS wild type mutational status confers a survival advantage in pancreatic ductal adenocarcinoma.

Windon AL et al.

Journal of Gastrointestinal Oncology, 2018

RET Aberrations in Diverse Cancers: Next-Generation Sequencing of 4,871 Patients.

Kato S et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017

27683183 (PubMed )
Supplement: 10780432ccr161679-sup-168576_1_supp_3636667_wcc1ns.docx

In Vitro and In Vivo Activity of Lucitanib in FGFR1/2 Amplified or Mutated Cancer Models.

Guffanti F et al.

Neoplasia (new York, N.y.), 2017

Case report: Durable response to afatinib in a patient with lung cancer harboring two uncommon mutations of EGFR and a KRAS mutation.

Tanizaki J et al.

Lung Cancer (amsterdam, Netherlands), 2016

Designing a high-throughput somatic mutation profiling panel specifically for gynaecological cancers.

Spaans VM et al.

Plos One, 2014

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.

Morris EJ et al.

Cancer Discovery, 2013

23614898 (PubMed )
Supplement: 21598290cd130070-sup-supplementary_figures_-_pdf_file_1385k.pdf

Multiparametric molecular characterization of pulmonary sarcomatoid carcinoma reveals a nonrandom amplification of anaplastic lymphoma kinase (ALK) gene.

Pelosi G et al.

Lung Cancer (amsterdam, Netherlands), 2012

Genomic profiling in a homogeneous molecular subtype of non-small cell lung cancer: An effort to explore new drug targets.

Veldore VH et al.

Indian Journal of Cancer, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."