Associated Papers
Constitutive activation of activin receptor-like kinase 3 in chondrocytes exacerbates skeletal dysplasia in mice with achondroplasia.
Jin M et al.
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 2025
Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy.
Chen J et al.
Journal of Orthopaedic Translation, 2025
Construction of a Lentiviral Vector for Fgfr2 Overexpression and its Impact on the Biological Behavior of Cranial Suture Mesenchymal Stem Cells.
Yue Y et al.
The Journal of Craniofacial Surgery, 2024
Targeting FGFR3 signaling and drug repurposing for the treatment of SLC26A2-related chondrodysplasia in mouse model.
Li P et al.
Journal of Orthopaedic Translation, 2024
Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice.
Loisay L et al.
Jci Insight, 2023
Cilia kinases in skeletal development and homeostasis.
Abraham SP et al.
Developmental Dynamics : an Official Publication of the American Association of Anatomists, 2022
Longitudinal Imaging of the Skull Base Synchondroses Demonstrate Prevention of a Premature Ossification After Recifercept Treatment in Mouse Model of Achondroplasia.
Rignol G et al.
Jbmr Plus, 2022
An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton.
Biosse Duplan M et al.
Disease Models & Mechanisms, 2021
FGFR3 in Periosteal Cells Drives Cartilage-to-Bone Transformation in Bone Repair.
Julien A et al.
Stem Cell Reports, 2020
Mouse Models of Syndromic Craniosynostosis.
Lee KKL et al.
Molecular Syndromology, 2019
Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies.
Kunova Bosakova M et al.
Human Molecular Genetics, 2018
Monoallelic FGFR3 and Biallelic ALPL mutations in a Thai girl with hypochondroplasia and hypophosphatasia.
Porntaveetus T et al.
American Journal of Medical Genetics. Part A, 2017
A point mutation in Fgf9 impedes joint interzone formation leading to multiple synostoses syndrome.
Tang L et al.
Human Molecular Genetics, 2017
Knock-in human FGFR3 achondroplasia mutation as a mouse model for human skeletal dysplasia.
Lee YC et al.
Scientific Reports, 2017
Fibroblast growth factor signaling in skeletal development and disease.
Ornitz DM et al.
Genes & Development, 2015
FGFR3 induces degradation of BMP type I receptor to regulate skeletal development.
Qi H et al.
Biochimica Et Biophysica Acta, 2014
Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models.
Su N et al.
Bone Research, 2014
The ras-GTPase activity of neurofibromin restrains ERK-dependent FGFR signaling during endochondral bone formation.
Ono K et al.
Human Molecular Genetics, 2013
Role of FGFs/FGFRs in skeletal development and bone regeneration.
Du X et al.
Journal of Cellular Physiology, 2012
An activating Fgfr3 mutation affects trabecular bone formation via a paracrine mechanism during growth.
Mugniery E et al.
Human Molecular Genetics, 2012
Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias.
Foldynova-Trantirkova S et al.
Human Mutation, 2012
The primary site of the acrocephalic feature in Apert Syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling.
Nagata M et al.
Bone, 2011
Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis.
Su N et al.
Human Molecular Genetics, 2010
Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome.
Twigg SR et al.
Developmental Dynamics : an Official Publication of the American Association of Anatomists, 2009
FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway.
Matsushita T et al.
Human Molecular Genetics, 2009
Gain-of-function mutation of FGFR3 results in impaired fracture healing due to inhibition of chondrocyte differentiation.
Su N et al.
Biochemical and Biophysical Research Communications, 2008
FGF signaling: its role in bone development and human skeleton diseases.
Su N et al.
Frontiers in Bioscience : a Journal and Virtual Library, 2008
FGF upregulates osteopontin in epiphyseal growth plate chondrocytes: implications for endochondral ossification.
Weizmann S et al.
Matrix Biology : Journal of the International Society for Matrix Biology, 2005
The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling.
Lievens PM et al.
The Journal of Biological Chemistry, 2004
Roles of FGF receptors in mammalian development and congenital diseases.
Coumoul X et al.
Birth Defects Research. Part C, Embryo Today : Reviews, 2003
Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations.
Cormier S et al.
The American Journal of Pathology, 2002
Somatic mutations of fibroblast growth factor receptor 3 (FGFR3) are uncommon in carcinomas of the uterine cervix.
Wu R et al.
Oncogene, 2000
Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis.
Chen L et al.
The Journal of Clinical Investigation, 1999