Varaico: Literature-Extracted Genetic Variants

Gene:FGFR4
Variant:p.N535D
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FGFR4

NM_213647.3:p.N535D

Associated Papers

Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors.

Vodicska B et al.

World Journal of Pediatrics : Wjp, 2023

36914906 (PubMed )
Supplement: 12519_2023_700_MOESM1_ESM.xlsx › Driver_list

A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors.

Marques Da Costa ME et al.

Communications Biology, 2023

37723198 (PubMed )
Supplement: 42003_2023_5320_MOESM4_ESM.xlsx › Suppl._Data_1

Infantile Rhabdomyosarcomas With VGLL2 Rearrangement Are Not Always an Indolent Disease: A Study of 4 Aggressive Cases With Clinical, Pathologic, Molecular, and Radiologic Findings.

Cyrta J et al.

The American Journal of Surgical Pathology, 2021

FGFR4: A promising therapeutic target for breast cancer and other solid tumors.

Levine KM et al.

Pharmacology & Therapeutics, 2020

Insight into ponatinib resistance mechanisms in rhabdomyosarcoma caused by the mutations in FGFR4 tyrosine kinase using molecular modeling strategies.

Wu C et al.

International Journal of Biological Macromolecules, 2019

Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations.

Gallo LH et al.

Cytokine & Growth Factor Reviews, 2015

DFG-out mode of inhibition by an irreversible type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors.

Huang Z et al.

Acs Chemical Biology, 2015

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4.

Tucker JA et al.

Structure (london, England : 1993), 2014

Fibroblast growth factor receptors, developmental corruption and malignant disease.

Kelleher FC et al.

Carcinogenesis, 2013

High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis.

Paulson V et al.

Genes, Chromosomes & Cancer, 2011

Targeting mutant fibroblast growth factor receptors in cancer.

Greulich H et al.

Trends in Molecular Medicine, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."