Associated Papers
Inhibition of FicD-mediated AMPylation and deAMPylation by Isoprenoid Diphosphates.
Blevins AM et al.
Biorxiv : the Preprint Server for Biology, 2025
AMPylation Regulates 5'-3' Exonuclease PLD3 Processing.
Hoffmann L et al.
Molecular & Cellular Proteomics : Mcp, 2025
A repurposed AMP binding domain reveals mitochondrial protein AMPylation as a regulator of cellular metabolism.
Gonzalez A et al.
Nature Communications, 2025
Small-Molecule FICD Inhibitors Suppress Endogenous and Pathologic FICD-Mediated Protein AMPylation.
Chatterjee BK et al.
Acs Chemical Biology, 2025
Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation.
Chatterjee BK et al.
Biorxiv : the Preprint Server for Biology, 2024
Discovery and validation of a novel inhibitor of HYPE-mediated AMPylation.
Camara A et al.
Cell Stress & Chaperones, 2024
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP.
Perera LA et al.
Embo Molecular Medicine, 2023
Deletion of mFICD AMPylase alters cytokine secretion and affects visual short-term learning in vivo.
McCaul N et al.
The Journal of Biological Chemistry, 2021
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.
Perera LA et al.
Nature Communications, 2021
Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD.
Fauser J et al.
Nature Communications, 2021
FICD activity and AMPylation remodelling modulate human neurogenesis.
Kielkowski P et al.
Nature Communications, 2020
An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.
Perera LA et al.
The Embo Journal, 2019
AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Preissler S et al.
Elife, 2017
FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP.
Preissler S et al.
Nature Structural & Molecular Biology, 2017
A Novel Fic (Filamentation Induced by cAMP) Protein from Clostridium difficile Reveals an Inhibitory Motif-independent Adenylylation/AMPylation Mechanism.
Dedic E et al.
The Journal of Biological Chemistry, 2016
AMPylation matches BiP activity to client protein load in the endoplasmic reticulum.
Preissler S et al.
Elife, 2015
HypE-specific nanobodies as tools to modulate HypE-mediated target AMPylation.
Truttmann MC et al.
The Journal of Biological Chemistry, 2015
Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.
Bunney TD et al.
Structure (london, England : 1993), 2014