Associated Papers
Exome sequencing reveals rare loss-of-function mutations in FLG and immune genes in patients with multiple food allergies.
Khanshour AM et al.
The Journal of Allergy and Clinical Immunology, 2026
Gene-environment interaction analysis in atopic eczema: evidence from large population datasets and modelling in vitro.
Standl M et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies.
Standl M et al.
Allergy, 2025
Novel Filaggrin Variants Are Associated with Ichthyosis Vulgaris in Mexicans.
González-Huerta LM et al.
Genes, 2025
Opportunistic genomic screening has clinical utility: An interventional cohort study.
Mighton C et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2025
Trajectories of egg sensitization in childhood: Two birth cohorts in Asia and Europe.
Nakamura T et al.
Allergy, 2025
Gene variants associated with skin barrier dysfunction in atopic dermatitis: a systematic review and meta-analysis.
Cordeiro PL et al.
Revista Paulista De Pediatria : Orgao Oficial Da Sociedade De Pediatria De Sao Paulo, 2025
Novel loss-of-function variants in filaggrin exon 3 in patients with severe atopic dermatitis.
Bellinato F et al.
Archives of Dermatological Research, 2024
Filaggrin Mutation Status and Prevention of Atopic Dermatitis with Maternal Probiotic Supplementation.
Zakiudin DP et al.
Acta Dermato-venereologica, 2024
Burden of Mendelian disorders in a large Middle Eastern biobank.
Aamer W et al.
Genome Medicine, 2024
Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort.
Virolainen SJ et al.
Jci Insight, 2024
Children with asthma and eczema carrying filaggrin loss-of-function mutations have increased antibiotic use through to adulthood.
Holden C et al.
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 2024
Influence of pathogenic filaggrin variants on dupilumab treatment in atopic dermatitis.
Clabbers J et al.
The Journal of Allergy and Clinical Immunology, 2024
Clinical-Genomic Analysis of 1261 Patients with Ehlers-Danlos Syndrome Outlines an Articulo-Autonomic Gene Network (Entome).
Wilson GN et al.
Current Issues in Molecular Biology, 2024
Filaggrin and beyond: New insights into the skin barrier in atopic dermatitis and allergic diseases, from genetics to therapeutic perspectives.
Stefanovic N et al.
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 2024
Phase separation as a possible mechanism for dosage sensitivity.
Yang L et al.
Genome Biology, 2024
Inflammation-related proteins in blood after dermal exposure to some common chemicals depend on the skin barrier gene filaggrin - a human experimental study.
Liljedahl ER et al.
Environmental Toxicology and Pharmacology, 2024
Relevance of Coding Variation in FLG And DOCK8 in Finnish Pediatric Patients with Early-Onset Moderate-To-Severe Atopic Dermatitis.
Perälä M et al.
Jid Innovations : Skin Science From Molecules to Population Health, 2023
Ichthyosis vulgaris: An updated review.
Jaffar H et al.
Skin Health and Disease, 2023
In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers.
Paul AA et al.
Frontiers in Molecular Biosciences, 2023
Phenotypes, endotypes and genotypes of atopic dermatitis and allergy in populations of African ancestry on the continent and diaspora.
Lunjani N et al.
Frontiers in Allergy, 2023
Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy.
Kalb B et al.
The Journal of Allergy and Clinical Immunology, 2022
Factors associated with severity of atopic dermatitis - a Finnish cross-sectional study.
Salava A et al.
Journal of the European Academy of Dermatology and Venereology : Jeadv, 2022
A small proline-rich protein (SPRR) gene variant contributes to atopic eczema and eczema-associated asthma susceptibility.
Dębińska A et al.
Postepy Dermatologii I Alergologii, 2022
Keratosis pilaris and filaggrin loss-of-function mutations in patients with atopic dermatitis - Results of a Finnish cross-sectional study.
Salava A et al.
The Journal of Dermatology, 2022
Genetic Variants in Epidermal Differentiation Complex Genes as Predictive Biomarkers for Atopic Eczema, Allergic Sensitization, and Eczema-Associated Asthma in a 6-Year Follow-Up Case-Control Study in Children.
Dębińska A et al.
Journal of Clinical Medicine, 2022
Revisiting the Roles of Filaggrin in Atopic Dermatitis.
Moosbrugger-Martinz V et al.
International Journal of Molecular Sciences, 2022
Early-life predictors and risk factors of peanut allergy, and its association with asthma in later-life: Population-based birth cohort study.
Kotsapas C et al.
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 2022
Increasing severity of early-onset atopic dermatitis, but not late-onset, associates with development of aeroallergen sensitization and allergic rhinitis in childhood.
Schoos AM et al.
Allergy, 2022
Prevalence of filaggrin loss-of-function variants in Chilean population with and without atopic dermatitis.
Cárdenas GV et al.
International Journal of Dermatology, 2022
Associations between child filaggrin mutations and maternal diet with the development of allergic diseases in children.
Venter C et al.
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 2022
Modelling trajectories of parentally reported and physician-confirmed atopic dermatitis in a birth cohort study.
Nakamura T et al.
The British Journal of Dermatology, 2022
Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors.
Arehart CH et al.
The Journal of Allergy and Clinical Immunology, 2022
The Skin and Nose Microbiome and Its Association with Filaggrin Gene Mutations in Pediatric Atopic Dermatitis.
van Mierlo MMF et al.
Dermatology (basel, Switzerland), 2022
Imputation provides an opportunity to study filaggrin ( FLG) null mutations in large population cohorts that lack bespoke genotyping.
Paternoster L et al.
Wellcome Open Research, 2022
Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study.
Bradshaw LE et al.
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 2021
Exome sequencing and analysis of 454,787 UK Biobank participants.
Backman JD et al.
Nature, 2021
Comparison of Epidermal Barrier Integrity in Adults with Classic Atopic Dermatitis, Atopic Prurigo and Non-Atopic Prurigo Nodularis.
Fölster-Holst R et al.
Biology, 2021
Four childhood atopic dermatitis subtypes identified from trajectory and severity of disease and internally validated in a large UK birth cohort.
Mulick AR et al.
The British Journal of Dermatology, 2021
Whole genome sequencing identifies novel genetic mutations in patients with eczema herpeticum.
Bin L et al.
Allergy, 2021
Increased Th22 cell numbers in a general pediatric population with filaggrin haploinsufficiency: The Generation R Study.
Looman KIM et al.
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 2021
Filaggrin Loss-of-Function Mutations Are Risk Factors for Severe Food Allergy in Children with Atopic Dermatitis.
Astolfi A et al.
Journal of Clinical Medicine, 2021
Filaggrin Polymorphisms and the Uptake of Chemicals through the Skin-A Human Experimental Study.
Rietz Liljedahl E et al.
Environmental Health Perspectives, 2021
Very Elevated IgE, Atopy, and Severe Infection: A Genomics-Based Diagnostic Approach to a Spectrum of Diseases.
Chin A et al.
Case Reports in Immunology, 2021
Rare occurrence of common filaggrin mutations in Turkish children with food allergy and atopic dermatitis
Vardar Acar N et al.
Turkish Journal of Medical Sciences, 2020
Mutations of filament-aggregating protein gene in Romanian children diagnosed with atopic dermatitis.
Chiriac AE et al.
Experimental and Therapeutic Medicine, 2020