Varaico: Literature-Extracted Genetic Variants

Gene:FLT3
Variant:p.I836L
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FLT3

NM_004119.3:p.I836L

Associated Papers

Novel molecular mechanisms of FLT3 deregulation: from the acute myeloid leukemia experience to therapeutic insights in acute lymphoblastic leukemia.

Lo Schiavo F et al.

Molecular Cancer, 2025

41126239 (PubMed )
Supplement: 12943_2025_2455_MOESM2_ESM.xlsx › Table_S1

Landscape of FLT3 Variations Associated with Structural and Functional Impact on Acute Myeloid Leukemia: A Computational Study.

Mirza Z et al.

International Journal of Molecular Sciences, 2024

RNA-seq-based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia.

Kubota H et al.

Blood Advances, 2024

38127276 (PubMed )
Supplement: BLOODA_ADV-2023-011583-mmc1.xlsx › Sup.9

Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia.

Gutierrez-Camino A et al.

British Journal of Cancer, 2024

38049555 (PubMed )
Supplement: 41416_2023_2511_MOESM1_ESM.pdf

A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations.

Yamaura T et al.

Blood, 2018

FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors.

Nguyen B et al.

Oncotarget, 2017

FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia.

Ma HS et al.

Cancer Research, 2014

Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia.

Kang HJ et al.

Leukemia Research, 2005

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.

Yamamoto Y et al.

Blood, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."